Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthma

International Immunology
Gap Ryol Lee, Richard A Flavell

Abstract

We have investigated the role of Th2 cytokines in the development of atopic diseases using transgenic mice carrying large genomic segments containing IL4, IL13 and IL5 genes and overexpressing these Th2 cytokines. In vitro stimulated, but not unstimulated, Th2 cells from the transgenic mice expressed high levels of IL4, IL13 and IL5 compared to those from non-transgenic mice. The transgenic mice developed spontaneous atopic dermatitis and airway inflammation against environmental allergens. The affected regions for atopic dermatitis covered the entire body including skin in the face, ear, eye-lid, neck, hind region and tail. Histological features showed thickened epidermis and dermis and infiltration of large numbers of inflammatory cells in the affected regions. The transgenic mice also showed airway inflammation characteristic of asthma, including infiltration of inflammatory cells and hypertrophy of airway epithelial cells. These mice also expressed high level of serum IgE, which is a hallmark of atopic diseases. In summary, this study provides additional evidence that Th2 cytokines play key roles in atopic diseases.

Citations

Nov 6, 2012·Progress in Lipid Research·Alexandra C Kendall, Anna Nicolaou
Sep 4, 2012·The Journal of Allergy and Clinical Immunology·Julia K GittlerEmma Guttman-Yassky
Jul 31, 2010·Immunology and Allergy Clinics of North America·Jonathan M Spergel
Aug 3, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jonathan M Spergel
Nov 3, 2009·Biological Psychology·Duck-Hee Kang, Michael T Weaver
Oct 17, 2015·Nature Reviews. Drug Discovery·Namita A GandhiGeorge D Yancopoulos
Nov 20, 2009·The Journal of Investigative Dermatology·Roshan GunathilakePeter M Elias
Dec 31, 2010·The Journal of Investigative Dermatology·Marie E ReichleLawrence S Chan
Nov 28, 2013·The Journal of Investigative Dermatology·Miyuki Omori-MiyakeJunji Yagi
Apr 9, 2008·The Journal of Allergy and Clinical Immunology·David J CousinsTak H Lee
Aug 22, 2006·Basic & Clinical Pharmacology & Toxicology·Thomas K Petersen
Feb 21, 2006·Clinics in Dermatology·Rochelle R TorgersonRoy S Rogers
Oct 3, 2008·The Journal of Investigative Dermatology·Claudia SchneiderLars Röse
Dec 4, 2014·International Immunopharmacology·Vengadeshprabhu KaruppagounderKenichi Watanabe
Aug 10, 2015·Cytokine·Richard D May, Michael Fung
Dec 31, 2014·Cellular and Molecular Life Sciences : CMLS·Adam SanMiguel, Elizabeth A Grice
Jul 3, 2016·American Journal of Clinical Dermatology·Diane Wang, Lisa A Beck
Jul 20, 2016·ELife·Josipa RaguzManuela Baccarini
Mar 21, 2018·Expert Review of Clinical Pharmacology·Marlene SeegräberAndreas Wollenberg
Apr 10, 2018·Journal of Toxicology and Environmental Health. Part a·Gwang-Ho JoYong Heo
Jul 1, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Atsushi OnoderaToshinori Nakayama
Sep 1, 2005·Current Opinion in Allergy and Clinical Immunology·Thirumalai R RamalingamThomas A Wynn
Dec 23, 2008·Expert Review of Molecular Diagnostics·Michael Wegmann
Aug 9, 2011·Current Opinion in Allergy and Clinical Immunology·Heidi Olze, Torsten Zuberbier
May 29, 2015·Biological Chemistry·Marina Le LamerMichel Simon
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Miyuki Omori, Steven Ziegler
Feb 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarita SehraMark H Kaplan
Jul 2, 2017·Archives of Dermatological Research·Jingling ZhaoThomas A Mustoe
Jun 6, 2018·Frontiers in Pharmacology·Baskaran PurushothamanJoon Myong Song
Oct 17, 2020·ImmunoTargets and Therapy·Andrea ChiricozziGiampiero Girolomoni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2022 Meta ULC. All rights reserved