PMID: 8608718Jan 1, 1996Paper

Transgenic models of human immunodeficiency virus type-1

Current Topics in Microbiology and Immunology
Paul E Klotman, A L Notkins

Abstract

Transgenic models have provided significant insights into HIV-1 pathogenesis, particularly with regards to Kaposi's sarcoma. HIV-associated nephropathy, the tissue-restricted expression of CNS strains of HIV-1, and the function of Nef in vivo. Both multigenic and single gene constructs have contributed to our understanding of HIV-1-induced diseases. While failing to provide models suitable for vaccine development, these transgenic models have provided great insight into HIV pathogenesis and may yet provide a means for the development and testing of molecular based therapies for AIDS.

Citations

Jul 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Roy L SutliffWilliam Lewis
May 3, 2002·Clinical and Diagnostic Laboratory Immunology·Chadd E Nesbit, Stanley A Schwartz
Oct 17, 2009·EMBO Reports·Alexander Ploss, Charles M Rice
May 16, 2019·American Journal of Physiology. Cell Physiology·Abiodun T KukoyiDavid M Guidot
Nov 30, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ricky MaungMarcus Kaul
Mar 4, 2008·American Journal of Respiratory Cell and Molecular Biology·Pratibha C JoshiDavid M Guidot
Sep 27, 2018·Journal of Cellular Physiology·Joseph Y CheungArthur M Feldman

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