PMID: 8937830Oct 1, 1996Paper

Transgenic models of neurodegenerative diseases

Current Opinion in Neurobiology
M K LeeD L Price

Abstract

Identification of genetic mutations linked to familial neurodegenerative diseases have made it possible to generate useful transgenic animal models. Studies using these transgenic animals indicate that many familial neurodegenerative diseases, such as motor neuron disease, Alzheimer's disease, prion diseases and trinucleotide repeat diseases, result from a gain of deleterious properties. The disease-specific pathology in transgenic mice demonstrates the utility of these models in elucidating pathogenic mechanisms of the disease and in developing therapeutic strategies.

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·V M VergeT Hökfelt
Dec 1, 1992·Nature Genetics·P St George-HyslopD Crapper McLachlan
Aug 28, 1992·Science·E R Stadtman
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Jul 1, 1989·Neurology·T SiddiqueM Speer
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P N HoffmanD L Price
Sep 1, 1968·Neurology·S Carpenter
May 1, 1984·Journal of Neuropathology and Experimental Neurology·A W ClarkD L Price
Nov 23, 1995·Nature·D W ClevelandR H Brown
Aug 1, 1995·Current Opinion in Neurology·P C Wong, D R Borchelt
Sep 1, 1995·Nature Medicine·W WascoD M Kovacs
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·K StottM Perutz
Aug 18, 1995·Science·E Levy-LahadG D Schellenberg
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·S RabizadehD E Bredesen
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·M E RippsJ W Gordon
Mar 1, 1995·Molecular and Cellular Biology·P J LapinskasV C Culotta
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·C A PardoD W Cleveland

❮ Previous
Next ❯

Citations

Nov 12, 1998·The Anatomical Record·H J Ralston
Jun 1, 1997·Trends in Pharmacological Sciences·E LouvelA Doble
Mar 26, 2005·Brain Research. Molecular Brain Research·Manuchair EbadiSushil K Sharma
Jul 5, 2005·Expert Opinion on Therapeutic Targets·P J Kahle, C Haass
Apr 23, 2008·Current Protocols in Neuroscience·Mandy JacksonJeffrey D Rothstein
Oct 28, 1998·Physiological Reviews·M R Picciotto, K Wickman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.