Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress

Neuroscience
R HansteinChristian Behl

Abstract

Corticotropin releasing hormone (CRH) is the central modulator of the mammalian hypothalamic-pituitary-adrenal (HPA) axis. In addition, CRH affects other processes in the brain including learning, memory, and synaptic plasticity. Moreover, CRH has been shown to play a role in nerve cell survival under apoptotic conditions and to serve as an endogenous neuroprotectant in vitro. Employing mice overexpressing murine CRH in the CNS, we observed a differential response of CRH-overexpressing mice (CRH-COEhom-Nes) to acute excitotoxic stress induced by kainate compared with controls (CRH-COEcon-Nes). Interestingly, CRH-overexpression reduced the duration of epileptic seizures and prevented kainate-induced neurodegeneration and neuroinflammation in the hippocampus. Our findings highlight a neuroprotective action of CRH in vivo. This neuroprotective effect was accompanied by increased levels of brain-derived neurotrophic factor (BDNF) in CRH-COEhom-Nes mice, suggesting a potential role for BDNF in mediating CRH-induced neuroprotective actions against acute excitotoxicity in vivo.

References

Jun 1, 1989·Neuron·Y A Barde
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M KorteT Bonhoeffer
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R ChenW W Vale
Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T BeckA Wree
Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·M W FoxF B Meyer
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·H LiuC G Wasterlain
Dec 22, 1999·Biological Psychiatry·T Steckler, F Holsboer
Nov 7, 2000·The Journal of Comparative Neurology·K Van PettP E Sawchenko
Nov 15, 2002·Trends in Endocrinology and Metabolism : TEM·Dimitris K Grammatopoulos, George P Chrousos
Apr 14, 2004·The European Journal of Neuroscience·Leonid G KhaspekovBeat Lutz
Oct 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yuncai ChenTallie Z Baram
Jan 15, 2005·Biochemical and Biophysical Research Communications·Erini DermitzakiAndrew N Margioris
May 14, 2005·Nature Reviews. Neuroscience·E Ron de KloetFlorian Holsboer
Jul 6, 2005·Ageing Research Reviews·Dick F SwaabPaul J Lucassen
Jul 28, 2005·Ageing Research Reviews·Nadhim Bayatti, Christian Behl
Aug 3, 2005·Nature Reviews. Neuroscience·Bai LuNewton H Woo
Aug 9, 2006·Journal of Neurochemistry·Jiyeon OckKyoungho Suk
Feb 13, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jan M DeussingWolfgang Wurst
Feb 24, 2007·Neuroscience Letters·Anja SchierlohGerhard Rammes
Dec 6, 2007·Epilepsia·Andres M Kanner

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Citations

Nov 26, 2009·Journal of Neuroscience Research·Katrin SonnDarya Kiryushko
Sep 10, 2014·Developmental Cell·Isabella GarciaBenjamin R Arenkiel
Aug 20, 2021·Frontiers in Endocrinology·Ifigeneia KassotakiDimitris K Grammatopoulos

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