Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation

American Journal of Physiology. Endocrinology and Metabolism
Greta TrogenJonathan M Peterson

Abstract

This study tested the ability of a novel adipose tissue derived cytokine, C1q TNF-related protein-3 (CTRP3), to prevent alcohol-induced hepatic lipid accumulation, or alcoholic fatty liver disease (ALD). Previous work has demonstrated that CTRP3 is effective at preventing high-fat diet-induced fatty liver; however, the potential of CTRP3 to inhibit ALD has not been explored. To test the potential protective effects of CTRP3, transgenic mice overexpressing CTRP3 (Tg) or wild-type littermates (WT) were subjected to one of two different models of ALD. In the first model, known as the NIAAA model, mice were fed control or alcohol-containing liquid diets (5% vol/vol) for 10 days followed by a single gavage of ethanol (5 g/kg). In the second model, the chronic model, mice were fed control or alcohol-containing diets for 6 wk with no gavage. This study found that CTRP3 reduced triglyceride accumulation in the chronic model of alcohol consumption by ~50%, whereas no reduction was observed in the NIAAA model. Further analysis of isolated primary hepatocytes from WT and Tg mice demonstrated that CTRP3 increased oxygen consumption in the presence of fatty acids, indicating that CTRP3 increases hepatic fatty acid utilization. In conclusion...Continue Reading

References

Jan 1, 1983·Alcoholism, Clinical and Experimental Research·D L Wang, R C Reitz
Nov 10, 1995·The Journal of Biological Chemistry·P E SchererH F Lodish
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mark J CzajaYongjun Wang
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Jul 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Guang W WongHarvey F Lodish
Jun 18, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carola M RosselandEllen Skarpen
Jan 13, 2006·Mitochondrion·Karima BegricheBernard Fromenty
Mar 17, 2006·Journal of Clinical Gastroenterology·Arthur J McCullough
Mar 1, 2006·Journal of Clinical Gastroenterology·Arthur J McCullough
Mar 18, 2008·Drug Discovery Today·David A FerrickCraig Beeson
Aug 30, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joanne M AjmoMin You
Sep 13, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G William WongHarvey F Lodish
Apr 9, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mariano MalaguarneraLucia Malaguarnera
Aug 4, 2009·Alcoholism, Clinical and Experimental Research·Katja BreitkopfSteven Dooley
Sep 18, 2009·The Journal of Biological Chemistry·Yasushi NoguchiGregory Stephanopoulos
Dec 17, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zheng ShenMin You
Jul 20, 2010·Drug and Alcohol Review·Jürgen RehmMichael Roerecke
Oct 19, 2010·The Journal of Biological Chemistry·Jonathan M PetersonG William Wong
Sep 17, 2011·Gastroenterology·Bin Gao, Ramon Bataller
May 1, 2012·Human Genetics·Kathleen R Merikangas, Vetisha L McClair
Mar 2, 2013·Nature Protocols·Adeline BertolaBin Gao
Jun 8, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jonathan M PetersonG William Wong
Jul 12, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jonathan M PetersonG William Wong
Oct 4, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Partha MukhopadhyayPal Pacher
Jul 11, 2014·World Journal of Gastroenterology : WJG·Hideki Fujii, Norifumi Kawada
Jan 19, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ting BaiJi-Xing Nan
Feb 28, 2016·Gastroenterology·Laura E NagyVijay H Shah
Sep 21, 2017·Nature Reviews. Gastroenterology & Hepatology·Richard ParkerBin Gao
Nov 2, 2017·PloS One·Yongjun LeeSun Young Kim

❮ Previous
Next ❯

Citations

Nov 8, 2018·PloS One·Ashley R DeGroatJonathan M Peterson
Dec 10, 2019·Physiological Reports·Greta TrogenJonathan M Peterson
Nov 11, 2020·International Journal of Molecular Sciences·Ming-Ling ChangSien-Sing Yang
Dec 4, 2020·PloS One·Arsham AlamianJonathan M Peterson

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
Assay
MDA

Software Mentioned

GraphPad Prism
Alphaview

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.