Transgenic plants as vaccine production systems

Trends in Biotechnology
H S Mason, C J Arntzen

Abstract

Transgenic plants that express foreign proteins with industrial or pharmaceutical value represent an economical alternative to fermentation-based production systems. Specific vaccines have been produced in plants as a result of the transient or stable expression of foreign genes. It has recently been shown that genes encoding antigens of bacterial and viral pathogens can be expressed in plants in a form in which they retain native immunogenic properties. Transgenic potato tubers expressing a bacterial antigen stimulated humoral and mucosal immune responses when they were provided as food. These results provide 'proof of concept' for the use of plants as a vehicle to produce vaccines.

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H S MasonC J Arntzen
Feb 1, 1988·The Journal of Experimental Medicine·H J de Aizpurua, G J Russell-Jones
May 25, 1996·Annals of the New York Academy of Sciences·R N BeachyM B Hein

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Citations

Oct 9, 2001·Biotechnology and Bioengineering·T S MorH S Mason
Sep 2, 2005·Plant Cell Reports·Tara L WalkerChris Collet
Nov 30, 2000·Current Infectious Disease Reports·J Yu, W H Langridge
Dec 19, 2003·Protein Expression and Purification·G B Sunil KumarV A Bapat
Jun 24, 2003·Comparative Immunology, Microbiology and Infectious Diseases·Philip B Carter, L E Carmichael
Jan 1, 1997·Comparative Immunology, Microbiology and Infectious Diseases·K Danner
Sep 16, 1999·Journal of Biotechnology·M P BradleyP Bird
Dec 14, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Barry J LamphearJohn A Howard
Oct 11, 2003·Biotechnology Advances·S R Rao, G A Ravishankar
Dec 10, 1998·Trends in Microbiology·T S MorK E Palmer
May 18, 2000·Microbes and Infection·C O Tacket, H S Mason
Mar 1, 1997·Nature Biotechnology·C J Arntzen
Apr 7, 1998·Nature Biotechnology·T ArakawaW H Langridge
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·I Raskin
Jan 1, 2000·Pharmaceutical Biology·V A BapatP S Rao
Sep 18, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K OhyaC Sugimoto
May 30, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kenji OhyaTakeshi Matsumura
Jul 8, 2011·Omics : a Journal of Integrative Biology·Edna F Einsiedel
Mar 1, 1996·Environmental Health Perspectives·K Brown
Sep 24, 1999·Biological Chemistry·R FischerN Emans
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·E Hansen, C G Kawashima
Sep 11, 1999·Parasitology Today·C J LilleyH J Atkinson
Oct 1, 2011·Biotechnology Advances·Parvaiz AhmadF Al-Qurainy
Mar 1, 1996·Journal of Travel Medicine·L RichterC J Arntzen
Mar 1, 2005·Vaccine·Carol O Tacket
Apr 10, 2003·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·W Mark Saltzman
Apr 22, 2006·Yi chuan xue bao = Acta genetica Sinica·Mei HanZhi-Gang An
May 25, 2004·Expert Opinion on Biological Therapy·Carol O Tacket
Apr 29, 1999·Annals of Medicine·F Dorner, P N Barrett

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