Transgenic technology for visualization and manipulation of the neural circuits controlling behavior in zebrafish

Development, Growth & Differentiation
Hitoshi OkamotoHidenori Aizawa

Abstract

The vertebrate brain is innately equipped with neural circuits that make quick behavioral decisions possible. Elucidating these neural circuits, determining how their master plans are encoded in the genome, and revealing how they can be modified by postnatal experiences will facilitate our understanding of how nature and nurture interact to establish an animal's behavior. In this review, we explain how transgenic zebrafish can cast insights into the developmental mechanisms and functional roles of the neural circuits that directly and indirectly control visuomotor behavior, by taking as an example a transgenic line Tg(brn3a-hsp70:GFP) enabling visualization of the tectobulbar and habenulo-interpeduncular tracts. These insights emphasize the benefits of applying advanced transgenic technology in zebrafish to future research into this area.

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Citations

Mar 10, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Eric W KleeStephen C Ekker
Jun 30, 2009·Seminars in Cell & Developmental Biology·Miguel L ConchaAlicia Colombo
Nov 18, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Seung-Hyun JungCheol-Hee Kim
Apr 23, 2015·The European Journal of Neuroscience·Cameron WyattEmre Yaksi
Jun 17, 2008·Zebrafish·Marnie E HalpernSteven D Leach
Mar 13, 2010·Experimental Animals·Hitoshi Okamoto, Akiko Ishioka

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