PMID: 6110191Feb 26, 1981Paper

Transglutaminase modifies the carboxy-terminal intracellular region of HLA-A and -B antigens

Nature
J S Pober, J L Strominger

Abstract

The HLA-A and -B antigens, encoded in the major histocompatibility complex, are transmembrane proteins whose carboxy termini project inwards from the cell membrane. The intracellular region of the HLA-B7 antigen is known to include two glutamine residues. We have used guinea pig transglutaminase to show that in vitro the enzyme couples amines specifically to glutamine residues in the carboxy-terminal region of the HLA-B7 and -A2 antigens. The specificity of this reaction has an immediate practical significance, but may also have a wider biological interest.

References

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Citations

Dec 1, 1984·Molecular Immunology·L FésüsM Sándor
Jul 26, 1985·Biochimica Et Biophysica Acta·S BeninatiF Autuori
Jul 31, 1986·Biochemical and Biophysical Research Communications·R PortaG Illiano
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R T Ambron, L T Kremzner
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L M SmithH M McConnell
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G A BerbersW W de Jong
Apr 5, 2000·Journal of Pediatric Gastroenterology and Nutrition·O MolbergL M Sollid
May 1, 1983·Medical Hypotheses·F E Barr
Dec 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B DobbersteinL Roberts

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