Transglutaminases: nature's biological glues

The Biochemical Journal
Martin GriffinCarlo M Bergamini


Transglutaminases (Tgases) are a widely distributed group of enzymes that catalyse the post-translational modification of proteins by the formation of isopeptide bonds. This occurs either through protein cross-linking via epsilon-(gamma-glutamyl)lysine bonds or through incorporation of primary amines at selected peptide-bound glutamine residues. The cross-linked products, often of high molecular mass, are highly resistant to mechanical challenge and proteolytic degradation, and their accumulation is found in a number of tissues and processes where such properties are important, including skin, hair, blood clotting and wound healing. However, deregulation of enzyme activity generally associated with major disruptions in cellular homoeostatic mechanisms has resulted in these enzymes contributing to a number of human diseases, including chronic neurodegeneration, neoplastic diseases, autoimmune diseases, diseases involving progressive tissue fibrosis and diseases related to the epidermis of the skin. In the present review we detail the structural and regulatory features important in mammalian Tgases, with particular focus on the ubiquitous type 2 tissue enzyme. Physiological roles and substrates are discussed with a view to increa...Continue Reading


Oct 19, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Emmett P BroderickAbhay S Pandit
Sep 24, 2008·Applied Microbiology and Biotechnology·Yu-Jen YuMing-Te Yang
Nov 28, 2012·Applied Microbiology and Biotechnology·Tobias HeckLinda Thöny-Meyer
Mar 23, 2012·Seminars in Immunopathology·Cornelius KlöckChaitan Khosla
Jan 4, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Soichiro YamamotoSatoshi Okinami
Jul 3, 2008·Planta·T KusanoY Takahashi
Jun 22, 2007·Amino Acids·P Kotsakis, M Griffin
Mar 29, 2007·Amino Acids·R IentileM Griffin
Jul 5, 2008·Amino Acids·Ivana CaputoCarla Esposito
Jul 10, 2008·Amino Acids·Richard L EckertEllen A Rorke
Jul 4, 2008·Amino Acids·Angelo Facchiano, Francesco Facchiano
Jul 16, 2008·Amino Acids·Donatella Serafini-FracassiniStefano Del Duca
Jul 3, 2008·Amino Acids·Angela SorrentinoLoredana Mariniello
Aug 13, 2008·Amino Acids·Carlo CervellatiAlberto Spisni
Nov 29, 2008·Amino Acids·Simone BeninatiMauro Piacentini
Dec 25, 2009·Amino Acids·Carlo M BergaminiRita Casadio
Aug 6, 2011·Amino Acids·Zhuo Wang, Martin Griffin
Aug 2, 2011·Amino Acids·Daniela CaccamoRiccardo Ientile
Nov 15, 2011·Amino Acids·Mileidys Perez AleaSaïd El Alaoui
Dec 24, 2011·Amino Acids·Stephanie DeaseyMaria Nurminskaya
Jan 11, 2012·Amino Acids·Richard A JonesMartin Griffin
Feb 4, 2012·Amino Acids·Alessandro LentiniSimone Beninati

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.