Transglutaminases: nature's biological glues

The Biochemical Journal
Martin GriffinCarlo M Bergamini

Abstract

Transglutaminases (Tgases) are a widely distributed group of enzymes that catalyse the post-translational modification of proteins by the formation of isopeptide bonds. This occurs either through protein cross-linking via epsilon-(gamma-glutamyl)lysine bonds or through incorporation of primary amines at selected peptide-bound glutamine residues. The cross-linked products, often of high molecular mass, are highly resistant to mechanical challenge and proteolytic degradation, and their accumulation is found in a number of tissues and processes where such properties are important, including skin, hair, blood clotting and wound healing. However, deregulation of enzyme activity generally associated with major disruptions in cellular homoeostatic mechanisms has resulted in these enzymes contributing to a number of human diseases, including chronic neurodegeneration, neoplastic diseases, autoimmune diseases, diseases involving progressive tissue fibrosis and diseases related to the epidermis of the skin. In the present review we detail the structural and regulatory features important in mammalian Tgases, with particular focus on the ubiquitous type 2 tissue enzyme. Physiological roles and substrates are discussed with a view to increa...Continue Reading

Citations

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Sep 24, 2008·Applied Microbiology and Biotechnology·Yu-Jen YuMing-Te Yang
Nov 28, 2012·Applied Microbiology and Biotechnology·Tobias HeckLinda Thöny-Meyer
Mar 23, 2012·Seminars in Immunopathology·Cornelius KlöckChaitan Khosla
Jan 4, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Soichiro YamamotoSatoshi Okinami
Jul 3, 2008·Planta·T KusanoY Takahashi
Jun 22, 2007·Amino Acids·P Kotsakis, M Griffin
Mar 29, 2007·Amino Acids·R IentileM Griffin
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Aug 6, 2011·Amino Acids·Zhuo Wang, Martin Griffin
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Jan 11, 2012·Amino Acids·Richard A JonesMartin Griffin
Feb 4, 2012·Amino Acids·Alessandro LentiniSimone Beninati

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