Transient and persistent consequences of acute stress on long-term potentiation (LTP), synaptic efficacy, theta rhythms and bursts in area CA1 of the hippocampus

Synapse
T J ShorsA Breindl

Abstract

Previous studies reported that exposure to an acute stressor of restraint and intermittent tailshock impairs long-term potentiation (LTP) in area CA1 of the rat hippocampus. In the first experiment, the longevity of the stress-induced impairment of LTP was determined. LTP of the excitatory postsynaptic potential (EPSP) was impaired 2 but not 4 days after stressor cessation. Exposure to the stressor also persistently enhanced the synaptic response to the tetanic stimulation patterned after theta rhythm activity (10, 100 Hz bursts delivered at 5 Hz). In a second experiment, we tested the hypothesis that exposure to the stressor enhanced synaptic efficacy itself. EPSPs were recorded from freely moving rats before, during and after stressor exposure. The synaptic response was not enhanced during stressor exposure. Instead, cessation of the stressor (and perhaps movement associated with release from restraint) induced a transient (< 2 min) decrease in synaptic efficacy. To determine whether exposure to the stressor enhances endogenous theta rhythms in area CA1, electroencephalographic (EEG) recordings were obtained from freely moving rats before, during and after exposure to the stressor. The power of theta (4-8 Hz) and low frequenc...Continue Reading

References

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Citations

Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·Marcela B EcheverryElaine A Del Bel
Jun 28, 2002·Brain Research. Brain Research Reviews·E Roy John
Apr 30, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jill R TurnerJulie A Blendy
May 7, 2002·Learning & Memory·Kevin B Baker, Jeansok J Kim
Mar 1, 2007·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Mara Mather
Nov 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jeansok J KimHugh T Blair
Jun 19, 2004·The International Journal of Neuroscience·Ismail AbidinEmel Sahin
May 10, 2002·Hippocampus·Constantine PavlidesBruce S McEwen
Apr 14, 2004·The European Journal of Neuroscience·Rose-Marie VouimbaGal Richter-Levin
Sep 26, 2006·Journal of Neuroscience Research·Alexandra Kavushansky, Gal Richter-Levin
Aug 21, 2014·Hippocampus·Anupratap TomarThomas J McHugh
Dec 17, 2009·The International Journal of Neuropsychopharmacology·Anne AlbrechtOliver Stork
Mar 2, 2016·Hippocampus·Tomer Mizrachi Zer-Aviv, Irit Akirav
Jun 7, 2006·Stress : the International Journal on the Biology of Stress·Jeansok J KimTherese A Kosten
Jul 7, 2007·Stress : the International Journal on the Biology of Stress·Sâmia Regiane Lourenço JocaFrancisco Silveira Guimarães
Jan 1, 2008·Dose-response : a Publication of International Hormesis Society·Phillip R Zoladz, David M Diamond

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