Transient assembly of active materials fueled by a chemical reaction

Science
Job BoekhovenJan H van Esch

Abstract

Fuel-driven self-assembly of actin filaments and microtubules is a key component of cellular organization. Continuous energy supply maintains these transient biomolecular assemblies far from thermodynamic equilibrium, unlike typical synthetic systems that spontaneously assemble at thermodynamic equilibrium. Here, we report the transient self-assembly of synthetic molecules into active materials, driven by the consumption of a chemical fuel. In these materials, reaction rates and fuel levels, instead of equilibrium composition, determine properties such as lifetime, stiffness, and self-regeneration capability. Fibers exhibit strongly nonlinear behavior including stochastic collapse and simultaneous growth and shrinkage, reminiscent of microtubule dynamics.

References

Sep 26, 1997·Nature·F J NédélecS Leibler
Jan 1, 1997·Annual Review of Cell and Developmental Biology·A Desai, T J Mitchison
Mar 30, 2002·Science·George M Whitesides, Bartosz Grzybowski
Mar 24, 2004·Angewandte Chemie·Kjeld J C van BommelJan van Esch
Sep 28, 2005·Organic & Biomolecular Chemistry·Kjeld J C van BommelJan van Esch
Feb 14, 2006·The Journal of Physical Chemistry. B·Marcin FialkowskiBartosz A Grzybowski
Feb 23, 2008·Nature Reviews. Molecular Cell Biology·Eric Karsenti
Jun 1, 2010·Angewandte Chemie·Job BoekhovenJan H van Esch
Oct 5, 2010·Angewandte Chemie·István LagziBartosz A Grzybowski
Nov 26, 2010·Nature Chemistry·Andrew R HirstRein V Ulijn
Feb 22, 2012·Science·T AidaS I Stupp
Aug 30, 2012·Nature Communications·Yuan GaoBing Xu
Jun 13, 2013·Nature Communications·David Yu ZhangErik Winfree
Oct 24, 2013·Journal of the American Chemical Society·Sisir DebnathRein V Ulijn
Sep 6, 2014·Science·Felix C KeberAndreas R Bausch
May 28, 2015·Angewandte Chemie·Charalampos G PappasRein V Ulijn

❮ Previous
Next ❯

Citations

Jan 19, 2016·Nature Materials·Faifan TantakittiSamuel I Stupp
Feb 11, 2016·ACS Nano·J Alexander Liddle, Gregg M Gallatin
Sep 5, 2015·Science·Daan van der Zwaag, E W Meijer
Oct 16, 2015·Chemical Communications : Chem Comm·Robert Pascal, Addy Pross
Mar 25, 2016·Chemical Communications : Chem Comm·César A Angulo-Pachón, Juan F Miravet
Apr 5, 2016·Advanced Materials·Frank VersluisRienk Eelkema
Apr 6, 2016·Nature Nanotechnology·Irving R Epstein, Bing Xu
Apr 15, 2016·Macromolecular Rapid Communications·Linyi Bai, Yanli Zhao
Apr 23, 2016·Advanced Drug Delivery Reviews·Huaimin WangBing Xu
Apr 25, 2016·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Robert Pascal, Addy Pross
Jun 22, 2016·Nature Chemistry·Subhabrata MaitiLeonard J Prins
May 11, 2016·Nanoscale·Chengbiao YangZhimou Yang
Jul 22, 2016·Nature Chemistry·Shoji OnogiItaru Hamachi
Jun 18, 2016·Accounts of Chemical Research·Fanny TrauselRienk Eelkema
Jul 7, 2016·Nature Nanotechnology·Bartosz A Grzybowski, Wilhelm T S Huck
Mar 1, 2016·Chemical Communications : Chem Comm·Jorge Leira-IglesiasThomas M Hermans
Aug 6, 2016·Chemical Communications : Chem Comm·Yun YanBen Zhong Tang
Aug 18, 2016·Chemistry : a European Journal·Nishant SinghBeatriu Escuder
Nov 1, 2016·Journal of the American Chemical Society·Richard HaburcakBing Xu
Jan 11, 2017·Angewandte Chemie·Sjoerd G J PostmaWilhelm T S Huck
Mar 3, 2017·ACS Applied Materials & Interfaces·Jie ZhanZhimou Yang
Jan 26, 2017·Current Opinion in Biotechnology·Flavio Della SalaLeonard J Prins
Apr 12, 2017·Journal of the American Chemical Society·Dávid KomáromySijbren Otto
Apr 27, 2017·Chemical Society Reviews·David B AmabilinoJonathan W Steed
May 4, 2017·Angewandte Chemie·Angelica Mariani, John D Sutherland
Apr 19, 2017·Chemical Society Reviews·Gonen AshkenasyAnnette F Taylor
May 11, 2017·Angewandte Chemie·Jugal Kishore SahooRein V Ulijn
May 10, 2017·Angewandte Chemie·Yasunori Okamoto, Thomas R Ward
Jan 31, 2017·Chemical Society Reviews·Rémi Merindol, Andreas Walther
Jun 10, 2017·Science·Ayala LampelRein V Ulijn
May 26, 2017·Chemistry : a European Journal·Jack L-Y ChenLeonard J Prins
Jul 14, 2017·Nature Communications·Michika OnodaRyo Yoshida
Jul 14, 2017·Chemical Society Reviews·Bartosz A GrzybowskiSteve Granick
Jul 14, 2017·Chemical Society Reviews·Susan A P van RossumJob Boekhoven
Jul 15, 2017·Chemical Communications : Chem Comm·Hirohiko YuasaTaisuke Banno
Jul 4, 2017·Journal of the American Chemical Society·Bas G P van RavensteijnWillem K Kegel
Apr 1, 2018·Nature Communications·Ananya MishraSubi J George
May 6, 2016·Chemical Society Reviews·Emil Roduner, Shankara Gayathri Radhakrishnan
Nov 15, 2017·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Olga TaranDavid G Lynn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.