Transient Asymptomatic Pulmonary Opacities During Osimertinib Treatment and its Clinical Implication

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Hansang LeeMyung-Ju Ahn

Abstract

Osimertinib is an oral, potent, irreversible third-generation EGFR tyrosine kinase inhibitor approved for the treatment of T790M-positive NSCLC patients who failed first- or second-generation EGFR tyrosine kinase inhibitors. Interstitial lung disease (ILD) is a rare complication with osimertinib, occurring in 1% to 3% of patients. Recently, a relatively high incidence of transient asymptomatic pulmonary opacities (TAPOs), which are different from ILD, has been described. However, its clinical implication has not been fully determined yet. We retrospectively analyzed 74 EGFR T790M mutant NSCLC patients treated with osimertinib. Serial computed tomographic findings were reviewed by a thoracic radiologist independently, and TAPO was classified according to its radiologic pattern. We also analyzed the correlation of TAPO with clinical outcomes. Among 74 patients, TAPOs were found in 15 (20.3%). The median time to TAPO development was 24.0 weeks (range, 1 to 72 weeks) and the median duration of TAPO was 6.0 weeks (range, 5 to 24 weeks) during continued osimertinib treatment. The most common radiological patterns of TAPO include cryptogenic organizing pneumonia and/or simple eosinophilic pneumonia. There was no significant difference...Continue Reading

Citations

Jan 8, 2019·International Journal of Cancer. Journal International Du Cancer·Lilan YiJian Zhang
Aug 31, 2019·Case Reports in Oncological Medicine·Michael J Forte, Rahul G Sangani
Jul 17, 2020·Targeted Oncology·Wonyoung ChoiYoungjoo Lee
Jun 13, 2020·Respiratory Medicine Case Reports·Chie WatanabeAkihiko Kawana
Aug 25, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ho Yun Lee
Sep 23, 2021·Der Radiologe·Katharina Hellbach
Nov 27, 2021·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Shravan SridharLoren H Ketai

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