Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion

The Journal of Physiology
Dimitrios KadasCarsten Duch

Abstract

We combine in situ electrophysiology with genetic manipulation in Drosophila larvae aiming to investigate the role of fast calcium-activated potassium currents for motoneurone firing patterns during locomotion. We first demonstrate that slowpoke channels underlie fast calcium-activated potassium currents in these motoneurones. By conducting recordings in semi-intact animals that produce crawling-like movements, we show that slowpoke channels are required specifically in motoneurones for maximum firing rates during locomotion. Such enhancement of maximum firing rates occurs because slowpoke channels prevent depolarization block by limiting the amplitude of motoneurone depolarization in response to synaptic drive. In addition, slowpoke channels mediate a fast afterhyperpolarization that ensures the efficient recovery of sodium channels from inactivation during high frequency firing. The results of the present study provide new insights into the mechanisms by which outward conductances facilitate neuronal excitability and also provide direct confirmation of the functional relevance of precisely regulated slowpoke channel properties in motor control. A large number of voltage-gated ion channels, their interactions with accessory su...Continue Reading

References

Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T ElkinsC F Wu
Aug 1, 1987·The Journal of Physiology·B Lancaster, R A Nicoll
Apr 24, 1981·Science·L Salkoff, R Wyman
Apr 14, 1999·Journal of Neurophysiology·C A del NegroS H Chandler
Jun 10, 2000·Journal of Neurophysiology·M Martin-Caraballo, J J Greer
Jan 3, 2001·Developmental Biology·B Hoang, A Chiba
May 17, 2002·Progress in Neurobiology·Pankaj Sah, E S Louise Faber
Feb 20, 2003·Nature Neuroscience·Gytis BaranauskasD James Surmeier
Sep 18, 2003·Development·Miki FujiokaJames B Jaynes
Feb 10, 2004·Neuron·Ole Kiehn, Klas Kullander
Mar 23, 2004·The Journal of Physiology·Giacomo RaffaelliEnrico Cherubini
Mar 30, 2004·The Journal of Physiology·Xiao-Ping SunAlan D Grinnell
Apr 7, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·E S Louise Faber, Pankaj Sah
Apr 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary D Womack, Kamran Khodakhah
Aug 25, 2005·Trends in Neurosciences·Sten GrillnerFiona E N LeBeau
Sep 6, 2005·Current Biology : CB·Eve MarderAdam L Taylor
Feb 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lyle E FoxChun-Fang Wu
May 24, 2006·Genes, Brain, and Behavior·J Y YuN S Atkinson
Sep 8, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Susanne LorenzThomas Sander
Nov 23, 2006·Nature Reviews. Neuroscience·Lawrence SalkoffAguan Wei
Oct 6, 2007·Molecular Neurobiology·Gytis Baranauskas
Jun 13, 2008·Developmental Neurobiology·Cortnie L HartwigSubhabrata Sanyal
Jun 14, 2008·Journal of Neurophysiology·Jason W Worrell, Richard B Levine
Sep 3, 2008·Pflügers Archiv : European journal of physiology·Narimane Benhassine, Thomas Berger
Feb 17, 2009·The Journal of Physiology·Gordon B Drummond
Apr 14, 2009·Nature Neuroscience·William N GrimesJeffrey S Diamond
Sep 12, 2009·Science·Henrik AlleJörg R P Geiger
Oct 16, 2009·Journal of Neurophysiology·Stefanie Ryglewski, Carsten Duch
Jun 25, 2010·Journal of Neurophysiology·Jennifer E SchaeferRichard B Levine

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Citations

Feb 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Natalie SchützlerCarsten Duch
Apr 12, 2019·ELife·Yelena KulikGraeme W Davis
Jan 16, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Patrick KratschmerJames E C Jepson
Jul 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Niklas KrickCarsten Duch

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