Transient CD80 expression defect in a patient with variable immunodeficiency and cyclic neutropenia

International Archives of Allergy and Immunology
C MoserH H Peter

Abstract

CD80 expression on stimulated B cells of 9 common variable immunodeficiency (CVID) patients and 10 healthy control individuals was examined. Here we report on an exceptional CVID patient with recurrent episodes of cyclic neutropenia, skin vasculitis and recurrent infections associated with a transient, but reproducible CD80 expression defect on stimulated B cells. Concomitantly serum Ig levels were markedly reduced and B cell counts were low. Interestingly, after recovery from an episode of neutropenia and vasculitis we observed an improvement of the CD80 expression as well as an increase in the number of B cells and a recovery of IgM and IgG production in vivo and in vitro.

Citations

May 18, 2011·Blood·Manuella L Gomes OchtropHans Hartmut Peter
Jan 18, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Aaron Chen AngusFook Tim Chew
May 1, 2001·Journal of Paediatrics and Child Health·T F LeungP M Yuen
Apr 17, 1998·Immunopharmacology and Immunotoxicology·N Y ViskovaV I Dizha

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