PMID: 9422252Dec 1, 1995Paper

Transient cognitive impairment during subclinical epileptiform electroencephalographic discharges

Seminars in Pediatric Neurology
D G Kasteleijn-Nolst Trenité

Abstract

Short epileptiform discharges of 10 seconds or less in children with or without epilepsy are not noticed by clinical observation of the child. These so-called subclinical discharges can however disturb cognition and influence daily performance at school and at home. Several studies have been performed to show the negative effect of these epileptiform electroencephalographic (EEG) discharges on choice reaction time tests, short term memory tests (verbal and nonverbal), and on school performance tasks such as reading, writing, and arithmetic. About one-half of children with subclinical discharges will show transient cognitive impairment during these discharges; those with predominantly left-sided discharges are poorer on reading and those with right-sided discharges are poorer on visual spatial tasks. Suppression of the EEG discharges with the antiepileptic drug valproic acid improved cognitive performance in two of six children; failure was because of side effects of the drug or insufficient suppression of the discharges. In individual cases, suppression of the epileptiform EEG discharges can be beneficial. Evaluation of this effect is necessary by standardizing EEG and cognitive performance measures. Furthermore, the phenomenon...Continue Reading

References

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Citations

Mar 19, 2009·Der Nervenarzt·J Bauer, C Kronisch
Nov 17, 2009·Der Nervenarzt·J Bauer, M Neumann
Nov 19, 2002·Pediatric Neurology·Nicole LaporteSophie Ghariani
Dec 23, 2004·Archives of Disease in Childhood·T Deonna
Apr 6, 2002·Brain & Development·Nesrin SenbilYahya Kemal Yavuz Gürer
Jul 20, 2011·Epilepsy & Behavior : E&B·Joost Nicolai, Dorothée Kasteleijn-Nolst Trenité
Feb 5, 2011·Neuroscience Letters·Eneida Porras-KattzElizabeth Valencia-Solís
Sep 28, 2010·Epilepsy & Behavior : E&B·Dobrinko SocanskiTor Ketil Larsen
Jan 18, 2005·Epilepsy & Behavior : E&B·Dorothée G Kasteleijn-Nolst Trenité, Roland Vermeiren
Mar 17, 2006·Epilepsy & Behavior : E&B·Gregory L Holmes, Pierre-Pascal Lenck-Santini
Jan 18, 2006·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Elaine WirrellSharon Whiting
Feb 5, 2009·Neurosurgery·Tobias LoddenkemperElaine Wyllie
Aug 30, 2011·Clinical EEG and Neuroscience·J Gordon MillichapCynthia V Stack
Nov 24, 2005·Epilepsia·Carol Camfield, Peter Camfield

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