Transient decrease in interleukin-7 availability arrests B lymphopoiesis during pregnancy

European Journal of Immunology
Nabil BoscoA Rolink

Abstract

In mice, B lymphopoiesis is transiently arrested during pregnancy, and this is thought to be due to depletion of a hormone-sensitive bone marrow precursor. In this study, combining in vitro and in vivo approaches with detailed phenotypic and functional analysis of progenitor cells, we have investigated the effects of pregnancy on mouse B cell development. Recently, we characterized a BM progenitor called early progenitor with lymphoid and myeloid potential (EPLM) which, when cultured under B cell conditions, is the immediate precursor of pre-B1 cells. Results obtained show that during late pregnancy, B cell development was blocked at the EPLM-to-pre-B1 transition. This block was associated with a lack of IL-7 due to a down-regulation of IL-7 gene transcription. Moreover, we established that exogenously administered IL-7 could rescue B lymphopoiesis in pregnant mice. We conclude that during pregnancy, rather than directly depleting a hormone-sensitive B cell precursor, hormones dampen BM B cell development by fine-tuning IL-7 availability.

References

Apr 1, 1995·The Journal of Experimental Medicine·U von Freeden-JeffryR Murray
Nov 1, 1994·The Journal of Experimental Medicine·J J PeschonB L Davison
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·K L Medina, P W Kincade
Nov 1, 1993·The Journal of Experimental Medicine·K L MedinaP W Kincade
Jul 1, 1993·The Journal of Experimental Medicine·K H GrabsteinP J Morrissey
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T SudoS Nishikawa
Aug 17, 1999·The Journal of Clinical Investigation·S SrivastavaR Pacifici
Mar 31, 2000·European Journal of Immunology·R CeredigJ Andersson
Mar 30, 2001·The Journal of Biological Chemistry·M JakackaJ L Jameson
Jul 14, 2001·Nucleic Acids Research·C M Klinge
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·C RoggiaR Pacifici
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·H IgarashiP W Kincade
May 16, 2002·Blood·Terry J Fry, Crystal L Mackall
Jun 20, 2002·Endocrinology·Mark J EvansChristopher C Chadwick
Feb 14, 2004·Immunological Reviews·Antonius G RolinkFritz Melchers
Oct 21, 2004·European Journal of Immunology·Lena ErlandssonInga-Lill Mårtensson
Nov 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yuhao GaoRoberto Pacifici
May 24, 2005·European Journal of Immunology·Lena ErlandssonInga-Lill Mårtensson
Jun 2, 2005·Nature Reviews. Immunology·Patrick Matthias, Antonius G Rolink
Jun 23, 2005·European Journal of Immunology·Gina BalciunaiteAntonius G Rolink
Nov 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michaela Robbie RyanRoberto Pacifici
Nov 30, 2005·Immunological Reviews·Hans Carlsten
May 4, 2006·The Journal of Clinical Investigation·M Neale Weitzmann, Roberto Pacifici
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Indira Guleria, Mohamed H Sayegh
Jun 22, 2007·Immunity·Richard R HardyKenneth Dorshkind

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Citations

Mar 17, 2012·Seminars in Immunology·Rhodri Ceredig, Antonius G Rolink
Mar 17, 2012·Seminars in Immunology·Steven A Corfe, Christopher J Paige
May 28, 2016·Journal of Diabetes and Its Complications·Lauren Wedekind, Louiza Belkacemi
Sep 12, 2014·Biology of Reproduction·Damián O MuzzioFederico Jensen
Mar 14, 2009·Nature Reviews. Immunology·Rhodri CeredigGeoffrey Brown
Sep 19, 2014·Biological Research for Nursing·Melissa M SheltonMaureen W Groer
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takafumi YokotaYuzuru Kanakura
Feb 1, 2021·Animal Reproduction Science·Chi Sun YunNobuhiko Yamauchi

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