Transient defect in nitric oxide generation after rupture of fetal membranes and responsiveness to inhaled nitric oxide in very preterm infants with hypoxic respiratory failure

The Journal of Pediatrics
Outi AikioMikko Hallman

Abstract

To study antenatal risk factors and inflammatory responses during hypoxic respiratory failure (HRF) in infants of very low gestational age (VLGA, ≤32.0 weeks). Of a cohort of 765 VLGA infants, 144 required mechanical ventilation. Airway specimens from these patients were prospectively studied. Infants who developed HRF (oxygenation index >25) with echocardiographic diagnosis of pulmonary hypertension were treated with inhaled nitric oxide (iNO). Three gestation comparison groups were formed on the basis of specific antenatal complications: prolonged preterm rupture of membranes (PPROM), spontaneous preterm birth, and preeclampsia. Chest radiographs were studied and airway specimens were analyzed for concentrations of tumor necrosis factor-α, interleukin (IL)-6, IL-8, IL-10, IL-12p70, IL-1β, and nitrite + nitrate over 4 days. Seventeen (2.2% of all VLGA infants) developed HRF. In all 17 cases, PPROM complicated the antenatal course; these infants responded to iNO, regardless of infection or PPROM. The chest radiographs of HRF and non-HRF PPROM infants were similar. Airway proinflammatory cytokines and nitrite + nitrate levels were low in infants with HRF, but they increased during iNO treatment and remained elevated after discon...Continue Reading

References

Oct 1, 1993·Analytical Biochemistry·T P MiskoM G Currie
Mar 1, 1995·The Journal of Pediatrics·A PeliowskiC A Ryan
Feb 14, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·B JónssonG Noack
Oct 19, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·J R VyasS Kotecha
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·S H Abman
Aug 24, 2002·American Journal of Obstetrics and Gynecology·Emma J SimsDavid E Soper
Mar 27, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Naoki UgaHiroshi Tada
Nov 13, 2004·Biology of the Neonate·Deepika K KakkeraLance A Parton
Aug 2, 2005·Pharmacology & Therapeutics·Beata Wojciak-Stothard, Sheila G Haworth
Oct 11, 2008·Seminars in Fetal & Neonatal Medicine·Boris W KramerAlan H Jobe
Dec 11, 2008·American Journal of Perinatology·Valerie Y ChockUNKNOWN NICHD Neonatal Research Network
Jan 24, 2009·Clinics in Perinatology·Nandini Arul, G Ganesh Konduri
Oct 21, 2010·Physiological Reviews·Yuansheng Gao, J Usha Raj
Sep 21, 2011·Pediatrics·Lisa M AskieUNKNOWN Meta-analysis of Preterm Patients on Inhaled Nitric Oxide Collaboration

❮ Previous
Next ❯

Citations

Oct 3, 2013·Early Human Development·Robin H Steinhorn
Nov 13, 2015·Expert Opinion on Drug Metabolism & Toxicology·U KraemerD Tibboel
Mar 31, 2015·Journal of Perinatology : Official Journal of the California Perinatal Association·J SemberovaJ Miletin
Jun 26, 2012·The Journal of Pediatrics·Molly K Ball, Robin H Steinhorn
May 27, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·N Ambalavanan, J L Aschner
May 10, 2017·Archives of Disease in Childhood. Fetal and Neonatal Edition·Michelle BaczynskiAmish Jain
Apr 28, 2018·Pediatric Pulmonology·Birgitte J SchmidtInger M Jørgensen
Nov 5, 2015·Circulation·Steven H AbmanUNKNOWN American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Clinical C
Feb 22, 2018·Journal of Translational Medicine·Nicola PrincipiSusanna Esposito
Nov 16, 2019·Nature Reviews. Disease Primers·Bernard ThébaudAlan H Jobe
Sep 17, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Pia HärkinMikko Hallman
Apr 2, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ga Young ParkYun Sil Chang
Dec 12, 2018·Journal of Paediatrics and Child Health·Mohamed Shalabi AhmedPatrick J McNamara
Aug 29, 2020·International Journal of Molecular Sciences·Shih-Hsin Wang, Po-Nien Tsao
May 23, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Michelle BaczynskiAmish Jain
Sep 16, 2020·Pediatric Pulmonology·Erica MandellSteven H Abman
Jan 30, 2021·Seminars in Fetal & Neonatal Medicine·Praveen ChandrasekharanSteven H Abman
Oct 2, 2021·European Journal of Pediatrics·Cristina Ramos-NavarroUNKNOWN GEIDIS Research Network
Oct 4, 2019·Neonatology·Rebecca KettleUNKNOWN European iNO Registry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.