Transient degradation of myelin basic protein in the rat hippocampus following acute carbon monoxide poisoning

Neuroscience Research
Satoru WatanabeShinya Suzuki

Abstract

The neurotoxicity of carbon monoxide (CO) poisoning is a significant clinical problem, but its mechanisms remain unclear. Previous studies of CO-exposed rats showed spatial memory disturbances and degradation of myelin basic protein (MBP) in the brain; however, regional localization of the degradation was not analyzed. In the present study, we histologically determined the foci of CO effects in the hippocampus. Wistar rats were exposed to CO for 60min (1000ppm for 40min+3000ppm for 20min) and returned into room air. For histological evaluation, the animals were sacrificed 90min, 1, 7 and 14 days after CO exposure and the brain tissue was analyzed with hematoxylin-eosin (HE), Nissl and Gallyas myelin staining as well as immunohistochemistry for MBP and phosphorylated or nonphosphorylated neurofilament. No histological changes were observed on HE, Nissl or Gallyas staining. In contrast, we detected MBP reduction at 90min after CO exposure in the dentate gyrus and CA3, and the recovery of MBP was observed after 14 days. The immunoreactivity of neurofilament also changed after CO exposure. Nevertheless, water maze test showed no significant effects of CO exposure on spatial memory. Our findings demonstrate that CO poisoning causes ...Continue Reading

References

Mar 1, 1988·Postgraduate Medical Journal·I K HartN E Cunningham
Nov 26, 1998·The New England Journal of Medicine·A Ernst, J D Zibrak
Jun 22, 1999·Journal of Neuropathology and Experimental Neurology·X H ChenD H Smith
Apr 20, 2000·Toxicology·J A RaubS R Thom
Oct 4, 2002·The New England Journal of Medicine·Lindell K WeaverAlan H Morris
Oct 4, 2002·The New England Journal of Medicine·Stephen R Thom
Nov 14, 2003·Brain Research. Brain Research Protocols·Leticia F PettenuzzoMoacir Wajner
Jul 9, 2004·Emergency Medicine Australasia : EMA·Carlos D ScheinkestelDavid V Tuxen
Sep 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stephen R ThomPhyllis Gimotty
May 18, 2005·Journal of the Neurological Sciences·Axel Petzold
Aug 26, 2006·American Journal of Respiratory and Critical Care Medicine·Stephen R ThomKevin R Hardy
Oct 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yasushi SatohKunio Takishima

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Citations

Nov 22, 2012·Drug and Chemical Toxicology·Maryam GhorbaniAmir Hooshang Mohamadpour
Sep 30, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seyed Adel MoallemShabnam Shahsavand
Dec 17, 2014·Experimental Neurology·Aya D PusicRichard P Kraig

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