Transient effect of glucocorticoids on red blood cell insulin receptors

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
Pirro RDeR Lauro

Abstract

The effect of oral administration of dexamethasone or cortisone on circulating red blood cell (RBC) insulin receptors was evaluated in normal males before treatment and 24 h (day 1), 48 h (day 2) and 72 h (day 3) after the commencement of steroid administration. Dexamethasone induced a slight significant decrease of insulin binding (p less than 0.05) on days 1 and 3, whereas cortisone did not. Cortisone, on the other hand, produced transient reduction (i.e. insulin binding lower than mean -2 SD of control values) in six subjects out of eight on days 1, 2 or 3 varying from subject to subject. Binding impairment was due mainly to reduced receptor affinity, even if slight reduction of receptor concentration was detectable. Qualitatively the present data agree that impaired insulin binding is due mainly to reduced receptor affinity; however, the effect of steroids on RBC is not significant and persistent as that on monocytes. The less marked effect of dexamethasone and cortisone on RBC versus monocytes indicates that receptor modifications may be tissue specific.

Citations

Jul 1, 1984·Archives of Biochemistry and Biophysics·J H ImH D Kim
Feb 1, 1988·Diabetes/metabolism Reviews·M McMahonR Rizza
Aug 1, 1987·Journal of Endocrinological Investigation·A CamagnaG Salvo
Apr 1, 1991·Biochemical Medicine and Metabolic Biology·K K Gambhir, V R Agarwal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.