Transient elastography in the assessment of liver fibrosis in adult thalassemia patients

American Journal of Hematology
Mirella FraquelliMaria Domenica Cappellini

Abstract

Transient elastography (TE) is a valuable noninvasive technique of measuring liver stiffness and a reliable tool for predicting hepatic fibrosis in patients with chronic liver disease. The role of TE in patients with beta-thalassemia has not been extensively investigated. The present study aimed to evaluate the role of TE in the assessment of hepatic fibrosis in 115 adult patients with beta-thalassemia major (TM) (#59) or intermedia (TI) (#56). TE was performed according to current practice. Histologic data were obtained in 14 cases. Liver iron concentration was assessed by atomic absorption spectrometry and T2 magnetic resonance. In patients with TM, the proportion of anti-HCV positive viremic patients, median serum ferritin levels, and TE values were significantly higher than in TI. In the group of 14 patients who underwent liver biopsy, a significant positive correlation was observed between liver stiffness and fibrosis stage (r = 0.73, P = 0.003). Severe fibrosis is diagnosed with a sensitivity of 60% and a specificity of 89%, whereas cirrhosis is detected with a sensitivity of 100% and a specificity of 92%. At multivariate analysis, the variables independently associated with TE were ALT, GGT, and bilirubin levels in both ...Continue Reading

References

Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Oct 30, 1998·Magma·S I MavrogeniD Kermastinos
Jul 8, 1999·The New England Journal of Medicine·N F Olivieri
Oct 28, 1999·The New England Journal of Medicine
May 7, 2002·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Laurent SandrinMathias Fink
Dec 31, 2003·Ultrasound in Medicine & Biology·Laurent SandrinRobert Palau
Feb 28, 2004·Blood·Melody J CunninghamUNKNOWN Thalassemia Clinical Research Network
Apr 15, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Françoise Imbert-BismutThierry Poynard
May 28, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hidetsugu SaitoHiromasa Ishii
Nov 25, 2004·Hematology·Alan R CohenElliott Vichinsky
Feb 4, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marianne ZiolMichel Beaugrand
Aug 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cosimo CollettaMario Pirisi
Sep 16, 2005·The New England Journal of Medicine·Deborah Rund, Eliezer Rachmilewitz
Nov 30, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nathalie Ganne-CarriéMichel Beaugrand
Oct 6, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jayant A TalwalkarVictor M Montori
Dec 18, 2007·European Journal of Haematology·Tristan MiraultChristian Rose
Dec 21, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Umberto ArenaMassimo Pinzani
Dec 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Abdurrahman SagirDieter Häussinger
Apr 9, 2008·Gastroenterology·Mireen Friedrich-RustEva Herrmann
Apr 12, 2008·Journal of Cardiovascular Medicine·Tiziana CogliandroUNKNOWN Society for the Study of Thalassemia and Hemoglobinopathies (SoSTE)
Jun 24, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ze-Zhou Song
Sep 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ze-Zhou Song
Oct 7, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gunda MillonigSebastian Mueller
Dec 22, 2009·Journal of Hepatology·Gunda MillonigSebastian Mueller
Jan 12, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laurent CastéraVictor de Lédinghen

❮ Previous
Next ❯

Citations

Mar 28, 2013·Expert Opinion on Medical Diagnostics·Alberto Piperno
Jul 30, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Amir Ali HamidiehHossein Poustchi
Jul 6, 2013·American Journal of Hematology·Christopher KohTheo Heller
Mar 16, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hossein PoustchiFarhad Zamani
Jul 1, 2011·Pathology·Mark L BassettJane E Dahlstrom
Sep 21, 2013·European Journal of Radiology·Francesco PaparoGian Andrea Rollandi
May 18, 2016·Annals of the New York Academy of Sciences·Antoine N Saliba, Ali T Taher
Jun 15, 2011·Expert Review of Hematology·Caterina Borgna-Pignatti, Maria Rita Gamberini
Aug 5, 2020·BMC Gastroenterology·Alessandra MangiaEugenio Caturelli
Jun 24, 2020·Annals of Hematology·Marta BortolottiGiovanna Graziadei
Oct 10, 2020·International Journal of Hematology·Tahereh RostamiAmir Ali Hamidieh
Oct 24, 2020·British Journal of Haematology·Luke K L ChanHarold K K Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.