Transient elastography with the XL probe rapidly identifies patients with nonhepatic ascites

Hepatic Medicine : Evidence and Research
Anna KohlhaasSebastian Mueller

Abstract

In contrast with other elastographic techniques, ascites is considered an exclusion criterion for assessment of fibrosis stage by transient elastography. However, a normal liver stiffness could rule out hepatic causes of ascites at an early stage. The aim of the present study was to determine whether liver stiffness can be generally determined by transient elastography through an ascites layer, to determine whether the ascites-mediated increase in intra-abdominal pressure affects liver stiffness, and to provide initial data from a pilot cohort of patients with various causes of ascites. Using the XL probe in an artificial ascites model, we demonstrated (copolymer phantoms surrounded by water) that a transient elastography-generated shear wave allows accurate determination of phantom stiffness up to a water lamella of 20 mm. We next showed in an animal ascites model that increased intra-abdominal pressure does not affect liver stiffness. Liver stiffness was then determined in 24 consecutive patients with ascites due to hepatic (n = 18) or nonhepatic (n = 6) causes. The cause of ascites was eventually clarified using routine clinical, imaging, laboratory, and other tools. Valid (75%) or acceptable (25%) liver stiffness data could...Continue Reading

Citations

Feb 7, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Claudia SommererSebastian Mueller
May 7, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Salvatore PettaAntonio Craxì
Oct 13, 2016·World Journal of Gastroenterology : WJG·Hye Won Lee, Sang Hoon Ahn
Oct 21, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Felix PiechaSebastian Mueller
Apr 14, 2020·Hepatic Medicine : Evidence and Research·Joao Tiago SerraSebastian Mueller
Oct 23, 2018·World Journal of Gastroenterology : WJG·Franziska J AmmonSebastian Mueller
Oct 31, 2014·World Journal of Gastroenterology : WJG·Sebastian MuellerVanessa Rausch

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

PASW Statistics
FibroScan®
SPSS
FibroScan

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