Transient elevation of granulocyte colony-stimulating factor levels in cerebrospinal fluid at the initial stage of aseptic meningitis in children

Pediatric Research
K FukushimaT Shimbo

Abstract

At the early stage of aseptic meningitis, there is a transient increase in neutrophil counts in the cerebrospinal fluid. Some factors in the cerebrospinal fluid might induce migration of neutrophils into the cerebrospinal fluid. Granulocyte colony-stimulating factor (G-CSF) plays an important role, not only as a hemopoietic factor but also as a regulating factor for a biologic defense system by neutrophils in the foci of infection. To analyze the role of G-CSF on accumulating neutrophils in the cerebrospinal fluid, we have measured G-CSF levels in the cerebrospinal fluid of children with aseptic meningitis, paying particular attention to the phasal transition. Within the first 2 d from the onset, G-CSF levels in the cerebrospinal fluid were 223 +/- 97 ng/L, significantly higher than those of the patients without meningitis (p < 0.01). Beyond the second day after the onset, the G-CSF levels rapidly decreased to below the detectable level, even though the patients manifested meningeal signs and symptoms. There was a direct relationship between G-CSF levels and neutrophil counts in the cerebrospinal fluid (r = 0.763, p < 0.01). During the first 2 d after the onset, the G-CSF level in the cerebrospinal fluid in each case was remark...Continue Reading

Citations

Apr 7, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kousaku MatsubaraHiroshi Miyazaki
Feb 24, 2006·Infection and Immunity·Petra J G ZwijnenburgA Marceline van Furth
Apr 1, 1996·Archives of Disease in Childhood·C BührerM Obladen
Jun 17, 1998·Journal of Neuroimmunology·F LahrtzA Fontana
Feb 1, 1996·The Journal of Pediatrics·A IshiguroT Shimbo
Jun 18, 2016·Mediators of Inflammation·Tobias DahmTobias Tenenbaum
Feb 22, 2018·Journal of Neuroinflammation·Tobias DahmHenriette Rudolph
Feb 28, 2003·Clinical and Experimental Immunology·T SuzukiT Shimbo

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