Transient exposure to a physiologically-relevant concentration of calcium confers tobramycin resistance upon sessile cells of Pseudomonas aeruginosa

FEMS Microbiology Letters
B D Hoyle, J W Costerton

Abstract

Sessile populations of a mucoid Pseudomonas aeruginosa isolate generated in M-56 medium of 'low' (0.02 mM) or 'high' (2.5 mM) Ca2+ were treated with tobramycin (250 micrograms.ml-1), as were biofilms exposed transiently to 'high' Ca2+ medium. Viability decreased by over 99.9% within 8 h in the 'low' and 'high' samples, while transient Ca2+ exposure was protective. Dispersed sessile bacteria were as tobramycin sensitive as planktonic bacteria.

References

Aug 26, 1976·The New England Journal of Medicine·P A Di Sant'Agnese, P B Davis
Jan 1, 1987·Annual Review of Microbiology·J W CostertonT J Marrie
Jan 1, 1988·Gastrointestinal Radiology·S N GlickH Herlinger
Jan 1, 1984·Annual Review of Microbiology·R E Hancock
Nov 1, 1982·The Journal of Antimicrobial Chemotherapy·M P Slack, W W Nichols

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Citations

Mar 21, 2012·International Urogynecology Journal·Hiren PatelGina Sternschuss
Sep 1, 1993·Antimicrobial Agents and Chemotherapy·H YasudaT Yokota
Dec 8, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·R M Donlan

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