PMID: 8738120Apr 30, 1996

Transient expression of lyn gene in Purkinje cells during cerebellar development

Brain Research. Developmental Brain Research
S ChenD E Hillman

Abstract

Expression of the lyn gene, a member of sarcoma proto-oncogene family, was analyzed immunohistochemically during cerebellar development in the rat. Lyn immunoreactivity was intense in axons, dendrites and somata of Purkinje cells from gestational day 18 to postnatal day 15 and then decreased. lyn gene expression clearly followed the appearance and the maturation of dendritic arbors. A rapid decrease in Lyn protein, after the 18th postnatal day, left only a few scattered positive Purkinje cell somata in the adult. External and undifferentiated internal granule cells were weak in Lyn immunoreactivity but gradually increased during development. Clusters of positive granule cells were found along the Purkinje cell layer with parasagittal bands crossing the granular layer by 21 days. These bands persisted into adulthood. Cerebellar nuclei lacked immunoreactivity in early development but only fastigial neurons began to acquire lyn gene expression by the 15th postnatal day. The corresponding appearance of the lyn gene expression and the formation of Purkinje cell dendritic arbors suggests that Lyn protein is involved in dendrogenesis. On the other hand, the late onset of immunoreactivity in fastigial neurons and granule cells implies ...Continue Reading

References

Feb 1, 1991·Journal of Neuroscience Research·J M Le BeauG Walter
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C A CartwrightW Eckhart
Feb 1, 1989·Molecular and Chemical Neuropathology·C A IngrahamP F Maness
Jan 1, 1989·Brain Research. Developmental Brain Research·S Chen, D E Hillman
Dec 1, 1988·Brain Research·M Sudol
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C A RossS H Snyder
Sep 1, 1986·Developmental Biology·P F ManessD W Fults
Apr 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Superti-Furga, S A Courtneidge
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Related Concepts

Axon
Cerebellum
Dendrites
Immunocytochemistry
Purkinje Cells
SRC gene
Rats, Holtzman
Gene Expression Regulation, Developmental

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