Transient expression of the conserved zinc finger gene INSM1 in progenitors and nascent neurons throughout embryonic and adult neurogenesis.

The Journal of Comparative Neurology
Anne DugganJaime García-Añoveros

Abstract

INSM1 is a zinc-finger protein expressed in the developing nervous system and pancreas as well as in medulloblastomas and neuroendocrine tumors. With in situ hybridization combined with immunohistochemistry, we detected INSM1 mRNA in all embryonic to adult neuroproliferative areas examined: embryonic neocortex, ganglionic eminence, midbrain, retina, hindbrain, and spinal cord; autonomic, dorsal root, trigeminal and spiral ganglia; olfactory and vomeronasal organ epithelia; postnatal cerebellum; and juvenile to adult subgranular zone of dentate gyrus, subventricular zone, and rostral migratory stream leading to olfactory bulb. In most of these neurogenic areas, subsets of neuronal progenitors and nascent, but not mature, neurons express INSM1. For example, in developing cerebellum, INSM1 is present in proliferating progenitors of the outer external granule layer (EGL) and in postmitotic cells of the inner EGL, but not in mature granule cell neurons. Also, lining the neural tube from spinal cord to neocortex in mouse as well as human embryos, cells undergoing mitosis apically do not express INSM1. By contrast, nonsurface progenitors located in the basal ventricular and/or subventricular zones express INSM1. Whereas apical progeni...Continue Reading

References

Jun 1, 1979·Journal of Neurocytology·S N Lawson, T J Biscoe
Dec 22, 1978·Brain Research·H O Nornes, M Carry
Jun 1, 1985·The Anatomical Record·R W Young
Apr 1, 1968·Journal of Neuropathology and Experimental Neurology·P Rakic, R L Sidman
Jun 1, 1965·The Journal of Comparative Neurology·J Altman, G D Das
Jan 15, 1983·International Journal of Cancer. Journal International Du Cancer·J GerdesH Stein
May 20, 1994·Science·C Lois, A Alvarez-Buylla
Nov 1, 1995·Cerebral Cortex·F ValverdeL López-Mascaraque
Oct 28, 1996·The Journal of Comparative Neurology·P G Bhide
Aug 26, 1998·Journal of Neurobiology·J M García-VerdugoA Alvarez-Buylla
May 21, 1999·Neuroscience Letters·P CappelloA Fasolo
Mar 29, 2001·Genes & Development·J WuM Chalfie
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·D R Kornack, P Rakic
Aug 3, 2001·Neuroscience·B ClancyB L Finlay
Jan 22, 2002·Trends in Neurosciences·Till Marquardt, Peter Gruss
Feb 19, 2002·Nature Neuroscience·Bagirathy NadarajahJohn G Parnavelas
Jun 7, 2002·Nature·Kresimir LetinicPasko Rakic
Sep 3, 2002·Journal of Neuroscience Research·Philippe Taupin, Fred H Gage
Feb 21, 2003·Current Opinion in Neurobiology·Gord Fishell, Arnold R Kriegstein

❮ Previous
Next ❯

Citations

Jan 7, 2009·The Journal of Biological Chemistry·Tao ZhangMichael S Lan
Feb 28, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael S Lan, Mary B Breslin
Jun 6, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Silvia ZoniRoberto Lucchini
Jan 31, 2012·Neurotoxicology·Gerda RentschlerKarin Broberg
Mar 11, 2016·BMC Medical Genomics·Maykel Cruz-MonteagudoEduardo Tejera
Nov 8, 2015·Mechanisms of Development·Sarah M LorenzenJaime García-Añoveros
Feb 24, 2011·The Journal of Comparative Neurology·Andrew J CastiglioniJaime García-Añoveros
Jun 12, 2013·Developmental Biology·Marie A Forbes-OsborneAnn C Morris
Jul 16, 2013·Experimental Eye Research·Donika GallinaAndy J Fischer
May 30, 2015·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Gyuri KimMihi Yang
Sep 28, 2016·Gene Expression Patterns : GEP·Jennifer L Bosse, Heithem M El-Hodiri
Sep 20, 2015·American Journal of Clinical Pathology·Jason N RosenbaumRicardo V Lloyd
Mar 1, 2018·Journal of Neuropathology and Experimental Neurology·Heather M AmesFausto J Rodriguez
Jan 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Caitlin E MonaghanGail Mandel
Aug 22, 2017·Frontiers in Molecular Neuroscience·Yingzi HeHuawei Li
Mar 25, 2020·Advances in Anatomic Pathology·Andrew M Bellizzi
Sep 13, 2017·Frontiers in Molecular Neuroscience·Jie GongDong Liu
Mar 29, 2020·Cellular Oncology (Dordrecht)·B MahalakshmiBharath Kumar Velmurugan
Jan 14, 2017·Frontiers in Molecular Neuroscience·Cédric FranciusFrédéric Clotman
May 23, 2019·Molecular Cancer Research : MCR·Chiachen ChenMichael S Lan
May 7, 2009·Current Opinion in Neurology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.