Transient focal ischemia affects the cAMP second messenger system and coupled dopamine D1 and 5-HT1A receptors in the living monkey brain: a positron emission tomography study using microdialysis

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Hideo TsukadaT Kakiuchi

Abstract

Using positron emission tomography (PET) and microdialysis, the present study showed that neuronal damages after transient focal ischemia was partly induced by hyperactivation of the cyclic adenosine 3',5'-monophosphate (cAMP) second messenger system through modulations of dopamine D, and serotonin 5-HT1A receptors in the living brains of cynomolgus monkeys. Occlusion of the right middle cerebral artery for 3 hours suppressed CBF in the striatum, and reperfusion induced hyperperfusion in the neocortex and striatum of the occluded side. Six hours after reperfusion, the activity of the cAMP second messenger system assayed with [11C]rolipram was significantly facilitated in the neocortex and striatum where CBF was lowered more than 40% of normal during occlusion ("ischemic" area). Seven days later, impaired dopamine D1 and 5-HT1A receptor binding, measured with [11C]SCH23390 and [carbonyl-11C]WAY-100635, respectively, was observed in the ischemic area. Microdialysis analysis revealed that the striatal dopamine level provided a transient and marked increased during occlusion and after reperfusion, whereas the cortical serotonin level transiently increased only after reperfusion, and was at an undetectable level thereafter. Administ...Continue Reading

References

Mar 1, 1979·Stroke; a Journal of Cerebral Circulation·M J HarrisonP Jenner
May 1, 1977·Stroke; a Journal of Cerebral Circulation·K M WelchJ S Meyer
Jan 11, 1979·Nature·J W Kebabian, D B Calne
Feb 20, 1978·Acta Neuropathologica·K JellingerP Kothbauer
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·J LuthmanL Olson
Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A SwansonF R Sharp
Sep 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H HaraK Kogure
Jan 1, 1986·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·C HalldinG Sedvall
Oct 5, 1987·Neuroscience Letters·M Y GlobusP Scheinberg
Feb 1, 1988·Digestive Diseases and Sciences·W R Brugge, C A Burke
Oct 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S C HuangM E Phelps
Apr 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·K A OsborneD I Graham
Oct 14, 1986·European Journal of Pharmacology·A Basse-Tomusk, G V Rebec
Dec 1, 1993·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·H IshimaruY Maruyama
Aug 2, 1993·European Journal of Pharmacology·Y KanaiK Kogure
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S PappataL Di Giamberardino
Apr 22, 1996·European Journal of Pharmacology·V W PikeP M Grasby
Jun 13, 1996·European Journal of Pharmacology·T ArakiY Itoyama
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A R YoungJ C Baron
Feb 1, 1997·Behavioural Brain Research·N NakataK Kogure

❮ Previous
Next ❯

Citations

Mar 23, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Mireille LortieRobert A deKemp
Jul 25, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shigeyuki YamamotoEdward F Domino
Mar 25, 2009·Pharmacology & Therapeutics·Sarah Grimwood, Paul R Hartig
Jan 23, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hideo TsukadaNorihiro Harada
Sep 15, 2018·Behavioural Pharmacology·Jessica M PovroznikElizabeth B Engler-Chiurazzi
Feb 16, 2010·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Hideo Tsukada
Jun 12, 2013·The Journal of Pharmacology and Experimental Therapeutics·Xia-Yan ZhangEr-Qing Wei
Nov 17, 2009·The Journal of Pharmacology and Experimental Therapeutics·Akira T KawaguchiHideo Tsukada
Jun 14, 2017·Mediators of Inflammation·Paolo GelosaLaura Castiglioni
Jan 29, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hideo TsukadaNorihiro Harada
May 28, 2021·Journal of Medicinal Chemistry·Jiyun SunSteven H Liang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.