Transient global amnesia -- not always a benign process

Acta Neurologica Scandinavica
Y LamplM Lorberboym

Abstract

Transient global amnesia (TGA) is an episodic dysfunction of declarative memory, which is assumed to be a benign disorder. Brain perfusion single photon emission computed tomography (SPECT) was shown to be abnormal during the acute stage and to become normal with normalization of memory function. No data are known about the brain perfusion pattern among these patients with recurrent TGA. Sixteen patients with TGA were studied with an initial brain imaging during the acute stages of their attack, and a second imaging was performed after 3 months. In the event of a patients having a second abnormal brain perfusion HMPAO SPECT, a third imaging was performed after 1 year. Hypofusion perfusion was demonstrated in all cases during the acute stage. In all patients who had a first TGA, a normal SPECT was demonstrated after 3 months. In three patients with recurrent TGA, the brain perfusion remained abnormal after 3 months and after 1 year. A normal perfusion in TGA after 3 months can be expected in a patient with a first attack. In patients with recurrent TGA attacks, a persistent focal hypoperfusion can be expected. This subgroup of patients may demonstrate a non-benign type of TGA, eventually due to a different etiology of event.

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Citations

Jun 21, 2005·Lancet Neurology·Kerstin Sander, Dirk Sander
Oct 29, 2011·Neurologic Clinics·Gary Hunter
Jul 20, 2014·Seizure : the Journal of the British Epilepsy Association·YooSeok KwonSangYun Kim
Oct 7, 2006·Acta Neurologica Scandinavica·B Guillery-GirardF Eustache
Aug 3, 2005·Medical Hypotheses·Ole Solheim, Tora Skeidsvoll
Jul 10, 2009·Journal of Clinical Neurology·Youngsoon YangIl-Woo Han
Aug 7, 2019·Journal of Neurology·Katharina KammAndreas Zwergal
Jul 10, 2019·Stroke; a Journal of Cerebral Circulation·Michele RomoliPeter Malcolm Rothwell
Jun 16, 2021·Acta Neurologica Scandinavica·Jinseung KimKang Min Park

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