Transient Graves disease developing after surgery for Cushing disease

The American Journal of the Medical Sciences
Hiroyuki MoritaKeigo Yasuda

Abstract

A 49-year-old man, diagnosed as having Cushing disease in 1976 at the age of 26, underwent a Hardy operation 13 years after treatment with reserpine combined with pituitary radiation. In laboratory examinations before and 2 weeks after the successful surgery, the patient's serum thyroid hormones were found to be normal except for suppressed serum thyroid-stimulating hormone (TSH), and his serum anti-TSH receptor (TRAb) and anti-TSH receptor-stimulating antibodies (TSAb) were negative. Glucocorticoid supplemental treatment was withdrawn on the 15th day after surgery and was restarted on the 48th day, during which time there were no signs of an adrenal crisis. Sinus tachycardia, fine finger tremor, and enlarged thyroid gland, approximately the size of a thumb head, were observed on the 140th day after surgery. Thyrotoxicosis with increased serum TSAb and TRAb and high 24-h thyroid uptake of 123I was noted, indicating a diagnosis of Graves disease. No special treatment was prescribed, but his serum thyroid hormone levels started to decrease on the 140th day after the operation and returned to normal on the 520th day. Serum TRAb also spontaneously decreased, but the timing of the peak of serum TRAb was delayed 230 days from that of...Continue Reading

References

Jan 1, 1994·The Journal of Clinical Endocrinology and Metabolism·U Feldt-RasmussenP Carayon
May 1, 1993·The American Journal of the Medical Sciences·N YamakitaK Miura

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Citations

Sep 20, 2008·Thyroid : Official Journal of the American Thyroid Association·Yoh Hidaka, Ke-Ita Tatsumi
Jul 27, 2004·Clinical Endocrinology·Karsten MüssigFritz J Seif
Apr 27, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Tomohiro KawaguchiTeiji Tominaga
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Rosario PivonelloAnnamaria Colao
May 19, 2012·Equine Veterinary Journal. Supplement·N B HoldstockA L Fowden
Sep 8, 2020·Internal Medicine·Yuji HiromatsuKei Mukohara
Feb 19, 2005·Journal of Endocrinological Investigation·E ArikanA Tugrul
Aug 7, 2017·Clinical Case Reports·Arndis Audur SigmarsdottirRagnar Bjarnason
Apr 4, 2021·International Journal of Molecular Sciences·Rosa Maria ParagliolaSalvatore Maria Corsello

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