Transient hyperprolactinemia during cycle stimulation and its influence on oocyte retrieval and fertilization rates

Fertility and Sterility
W P HummelL M Talbert

Abstract

Prolactin (PRL) has been shown to have inhibitory effect on follicle-stimulating hormone induced aromatase activity and estrogen biosynthesis in human granulosa cells cultured in vitro. To investigate the validity of the hypothesis that transient hyperprolactinemia during controlled ovarian hyperstimulation might influence follicular steroidogenesis and oocyte maturation, we measured serum PRL, estradiol, and progesterone before aspiration of oocytes in women undergoing ovarian stimulation (n = 108) in in vitro fertilization-embryo transfer. No correlation was detected between PRL and total number oocytes, number mature oocytes, fertilization rate, cleavage rate, and pregnancy rate. Transient elevation of PRL was a common finding in patients (57%) but was not associated with a poor clinical outcome.

Citations

Sep 17, 2002·The American Journal of Chinese Medicine·Satoshi UsukiKatsumi Soreya
Jun 1, 1992·Journal of Assisted Reproduction and Genetics·D R MeldrumB Marr
Mar 3, 2001·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·N DoldiA Ferrari

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