Transient Hypothyroidism During Lactation Arrests Myelination in the Anterior Commissure of Rats. A Magnetic Resonance Image and Electron Microscope Study

Frontiers in Neuroanatomy
Federico S LuciaP Berbel

Abstract

Thyroid hormone deficiency at early postnatal ages affects the cytoarchitecture and function of neocortical and telencephalic limbic areas, leading to impaired associative memory and in a wide spectrum of neurological and mental diseases. Neocortical areas project interhemispheric axons mostly through the corpus callosum and to a lesser extent through the anterior commissure (AC), while limbic areas mostly project through the AC and hippocampal commissures. Functional magnetic resonance data from children with late diagnosed congenital hypothyroidism and abnormal verbal memory processing, suggest altered ipsilateral and contralateral telencephalic connections. Gestational hypothyroidism affects AC development but the possible effect of transient and chronic postnatal hypothyroidism, as occurs in late diagnosed neonates with congenital hypothyroidism and in children growing up in iodine deficient areas, still remains unknown. We studied AC development using in vivo magnetic resonance imaging and electron microscopy in hypothyroid and control male rats. Four groups of methimazole (MMI) treated rats were studied. One group was MMI-treated from postnatal day (P) 0 to P21; some of these rats were also treated with L-thyroxine (T4) f...Continue Reading

References

Feb 20, 1978·Anatomy and Embryology·M Marin-Padilla
Jan 1, 1975·International Review of Neurobiology·S G Waxman
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·L S Allen, R A Gorski
Dec 1, 1990·The Journal of Comparative Neurology·S DemeterG W Van Hoesen
Jul 1, 1988·Magnetic Resonance Imaging·J Hennig, H Friedburg
Sep 1, 1987·Journal of Child Psychology and Psychiatry, and Allied Disciplines·I Marks
Jan 1, 1987·Annual Review of Physiology·J H Dussault, J Ruel
Sep 1, 1969·Brain Research·R BalázsD A Wilson
Jul 1, 1984·The Journal of Clinical Endocrinology and Metabolism·L SavaR Vigneri
Mar 1, 1993·The Journal of Clinical Investigation·A Rodriguez-PeñaJ Bernal
Sep 16, 1994·Brain Research. Developmental Brain Research·A Guadaño FerrazP Berbel
Jan 1, 1995·Archives of Neurology·G W HyndM Cohen
Oct 20, 1994·Behavioural Brain Research·P BerbelJ Ramón Cerezo
Aug 1, 1997·The American Journal of Psychiatry·J PivenS Arndt
Jan 20, 1998·Brain Research Bulletin·M NoonanM A Sanfilippo
Feb 3, 1999·Experimental Brain Research·G Di VirgilioT Schaffner
Aug 24, 1999·Journal of Neurobiology·A Rodríguez-Peña
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Oct 10, 2001·Journal of Neuroscience Research·P C BarradasM S De Freitas
Mar 19, 2002·Brain Research·Jorge Larriva-SahdAlfredo Varela-Echavarria
Mar 28, 2003·Molecular Psychiatry·G M InnocentiJ Parnas
May 22, 2003·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Joanne F Rovet
Sep 19, 2003·Lancet·Dmitri TkachevSabine Bahn
Feb 10, 2004·Annals of the New York Academy of Sciences·David G Amaral
Sep 1, 1951·The Journal of Physiology·W A H RUSHTON
Jul 6, 2004·Neuroscience Letters·Michael J HaasArshag D Mooradian
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Monique H A KesterGabriella Morreale de Escobar
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Elizabeth N PearceLewis E Braverman
Jul 17, 2004·Endocrinology·Christopher M SchoonoverGrant W Anderson
Jan 16, 2007·Lancet·Susan P WalkerUNKNOWN International Child Development Steering Group
Oct 27, 2007·Trends in Endocrinology and Metabolism : TEM·Pere BerbelGabriella Morreale de Escobar
Nov 15, 2008·Seminars in Perinatology·Fiona L R Williams, Robert Hume
Nov 15, 2008·Seminars in Perinatology·Joanne Rovet, Nevena Simic
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael DavisChristian Grillon

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Citations

Jun 2, 2020·Frontiers in Endocrinology·Pieter VancampSylvie Remaud
Nov 25, 2019·Molecular and Cellular Endocrinology·Katherine L O'Shaughnessy, Mary E Gilbert
Jun 10, 2021·The Journal of Clinical Endocrinology and Metabolism·Katia PerriMohamad Maghnie

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Methods Mentioned

BETA
electron microscopy

Software Mentioned

ImageJ
Paravision
SYSTAT

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