Transient impaired cell-mediated tumor immunity after acute infection with lymphocytic choriomeningitis virus.

Scandinavian Journal of Immunology
F GüttlerP N Jorgensen

Abstract

Intraperitoneal injection of nononcogenic lymphocytic choriomeningitis (LCM) virus in adult C3H mice causes a symptomless infection but stimulates specific cell-mediated and humoral immune responses. However, median survival time of virus-infected mice inoculated with syngeneic tumor cells was significantly shortened, and growth of semiallogeneic tumors was significantly enhanced. Cell-mediated cytotoxicity measured as chromium-51 release from labeled tumor cells was significantly suppressed but was recovered within 55 days after infection. The suppressed immune responsiveness could be conferreo on a normal spleen cell population when activated in virus-infected recipients. Chronically LCM virus-infected mice showed an unimpaired cell-mediated immune response to tumor allografts.

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Citations

Sep 1, 1975·Scandinavian Journal of Immunology·E Gronowicz, A Coutinho
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dirk HomannMichael B A Oldstone
Dec 1, 1977·Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology·P J Christoffersen, K B Jørgensen

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