Transient increase of manganese-superoxide dismutase in remote brain areas after focal photothrombotic cortical lesion

Stroke; a Journal of Cerebral Circulation
H J BidmonK Zilles

Abstract

Free radicals including superoxide are responsible for postlesional cytotoxicity. In contrast to the constitutive CuZn-superoxide dismutases (SODs), manganese-superoxide dismutase (Mn-SOD) is inducible and has the potential to protect neurons by its superoxide dismutating activity. Therefore, we studied the presence and the regional changes in Mn-SOD within the brain after focal cortical ischemia. Focal cortical photothrombotic lesions were produced in the hindlimb region of rat brains. Animals were anesthetized and transcardially perfused with Zamboni's fixative. Mn-SOD was immunohistochemically localized using an antiserum against rat-Mn-SOD. Changes in Mn-SOD immunoreactivity were quantified by image analysis. Focal photothrombosis caused a perilesional increase in Mn-SOD after 24 hours, followed by a further significant increase at 48 hours in perilesional cortex, ipsilateral corpus callosum, hippocampus, and thalamus, as well as in a homotopic cortical area within the nonlesioned hemisphere. At day 2, Mn-SOD was present in neurons and astrocytes. Up to day 7, Mn-SOD increased in the entire ipsilateral and contralateral cortex but remained higher elevated in the ipsilateral hippocampus and thalamus. Thereafter, Mn-SOD decre...Continue Reading

References

Nov 1, 1992·Archives of Biochemistry and Biophysics·H IschiropoulosJ S Beckman
Feb 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J J GromeD I Graham
May 1, 1985·Annals of Neurology·B D WatsonM D Ginsberg
Jan 1, 1984·Journal of Neurochemistry·B D WatsonM D Ginsberg
Jan 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H KatoY Itoyama
Nov 1, 1994·Journal of Neuropathology and Experimental Neurology·J C Hedreen, V E Koliatsos
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T MatsuyamaM Sugita
Jan 1, 1996·Journal of Neuropathology and Experimental Neurology·W O Whetsell
Feb 1, 1996·Progress in Neurobiology·H J Luhmann
Feb 1, 1996·The Japanese Journal of Physiology·H NakazawaM Fujishima
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K SchieneO W Witte
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·R M LebovitzM M Matzuk
Jul 1, 1996·Chemical Research in Toxicology·J S Beckman
Oct 1, 1996·Archives of Neurology·M BakarR T Wertz
Oct 1, 1996·Archives of Neurology·M D Ginsberg
Aug 1, 1996·Behavioural Brain Research·N I WoodT C Hamilton
Oct 1, 1996·Journal of Neurotrauma·K NakauchiK Fukuzawa

❮ Previous
Next ❯

Citations

Feb 16, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Francis G BlankenbergMidori Anne Yenari
Mar 24, 2004·Free Radical Biology & Medicine·Amit BadhwarRichard F Potter
Jun 1, 2005·Progress in Neurobiology·F BlockM Loos
Jun 7, 2003·Brain Research. Brain Research Reviews·R R Leker, M Y Neufeld
May 23, 2001·Free Radical Biology & Medicine·B AhlemeyerJ Krieglstein
May 22, 2009·Journal of Neurochemistry·Marta Sidoryk-WegrzynowiczMichael Aschner
Aug 26, 2006·The European Journal of Neuroscience·Anja UrbachOtto W Witte
Apr 19, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jian YangEd X Wu
Feb 1, 2005·Behavioural Brain Research·Elena V ShaninaOtto W Witte
Jul 28, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jasenka Mrsić-PelcićGordana Zupan
Apr 20, 2004·Brain Research. Molecular Brain Research·Armin SchneiderJaroslaw Aronowski
Jan 13, 2015·Neurochemistry International·Joanna Ruszkiewicz, Jan Albrecht
Sep 29, 2011·Experimental Neurology·Vardit RubovitchChaim G Pick
Oct 12, 2012·International Journal of Occupational Medicine and Environmental Health·Yongyi WangYinyin Xia
Oct 29, 2000·Annals of Emergency Medicine·R W Neumar
May 20, 2014·Brain Research·Lena SchumacherOtto W Witte
Aug 19, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O W WitteG Hagemann
Nov 7, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jean-Claude BaronMatthias Endres
Feb 24, 2001·Human & Experimental Toxicology·V W Pentreath, N D Slamon
Feb 13, 2003·The European Journal of Neuroscience·S ReineckeO W Witte

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.