PMID: 8984526Oct 1, 1996Paper

Transient increases in albumin and hyaluronan in bronchoalveolar lavage fluid after quitting smoking: possible signs of reparative mechanisms

Respiratory Medicine
C M SköldA Eklund

Abstract

Inhalation of tobacco smoke results in an accumulation of cells in the lower respiratory tract. The inflammatory response in the alveoli and lung interstitium may also be reflected by increased bronchoalveolar lavage (BAL) fluid concentrations of extracellular matrix components. The present study investigated the influence of smoking on the BAL fluid concentrations of albumin (ALB), hyaluronan (HA) and fibronectin (FN). Lavage fluids from 18 smokers were analysed before and at 1, 3, 6, 9 and 15 months after smoking cessation. Never-smokers (n = 112) served as a reference group. The total cell concentration and the concentrations of macrophages, lymphocytes, neutrophils and eosinophils were higher (P < 0.001-0.01) in smokers' BAL fluid than in never-smokers', but the values returned to normal within 9 months of smoking cessation. The HA concentration was higher (P < 0.001) in smokers' than in never-smokers' BAL fluid, but FN and ALB did not differ. Transient increases in the concentrations of ALB and HA (P < 0.01 for both) was observed within 6 months of smoking cessation. These findings indicate a temporary heightened alveolar-capillary permeability and an increased production and/or degradation of HA, being enhanced following ...Continue Reading

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Citations

Feb 12, 2008·Intensive Care Medicine·Daniela NegriniAndrea Moriondo
Jun 18, 2010·The Journal of Biological Chemistry·Maria E MonzonRosanna Malbran Forteza
Oct 11, 2012·The Journal of Biological Chemistry·Rosanna Malbran FortezaMaria E Monzon
Nov 30, 2006·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Judith C StewartMark W Frampton
Jun 27, 2006·American Journal of Respiratory and Critical Care Medicine·Sylvia VerbanckWalter Vincken
May 22, 2013·Respiratory Research·Firdaus A A Mohamed HoeseinJan-Willem J Lammers
Nov 23, 2006·Critical Care : the Official Journal of the Critical Care Forum·Alba B Souza-FernandesPatricia R M Rocco
Sep 18, 2012·Preventive Medicine·Yuanying LiHiroyasu Iso
Oct 9, 2015·International Journal of Cell Biology·Mark E LauerMark A Aronica
Feb 28, 2007·Respiratory Medicine·Daiana StolzJörg D Leuppi
Jul 5, 2016·Pharmacology & Therapeutics·Linda SwedinMatthew C Catley
Aug 25, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Valérie BougaultLouis-Philippe Boulet

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