Jul 1, 1976

Transient inhibition of cell proliferation in rat glioma monolayer cultures by cortisol

Cancer Research
R J Grasso


The effect of 3 muM cortisol on cell proliferation in rat glioma (strain C6) monolayer cultures was investigated. Cell density measurements showed that cortisol-treated C6 cells continued to proliferate at maximum log phase rates for 1 to 2 days. Then cell proliferation ceased as growth in control cultures continued into stationary phase. A 2-day period of growth inhibition followed during which cell densities were 30 to 50% lower relative to controls. Growth resumed subsequently, and final cell densities were similar to those of controls. The presence of epicortisol (the biologically inactive isomer of cortisol) in the culture medium did not alter the rate of log phase growth relative to controls. During the initial period of continued growth after exposure to cortisol, the pH of the medium decreased at the same rate in control and treated cultures. During the growth-inhibitory period, erythrosin B dye was excluded equally well (greater than 94%) by control and treated cells, and no morphological differences were detected by phase contrast microscopy. When the culture medium was replaced daily, the control cells at elevated densities continued to proliferate at a reduced rate. In cortisol-treated cultures, the period of growth...Continue Reading

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Mentioned in this Paper

Hydrocortisone, (11 alpha)-Isomer
Cell Proliferation
Mixed Gliomas
Cell Division Phases
Inhibition of Cell Proliferation
Metabolic Inhibition
Glioblastoma Multiforme Pathway
Stationary Phase - Research Equipment

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