PMID: 9428524Jan 15, 1998Paper

Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres

Cell
K EkwallR C Allshire

Abstract

Histone acetylation may act to mark and maintain transcriptionally active or inactive chromosomal domains through the cell cycle and in different lineages. A novel role for histone acetylation in centromere regulation has been identified. Exposure of fission yeast cells to TSA, a specific inhibitor of histone deacetylase, interferes with repression of marker genes in centromeric heterochromatin, causes chromosome loss, and disrupts the localization of Swi6p, a component of centromeric heterochromatin. Transient TSA treatment induces a heritable hyperacetylated state in centromeric chromatin that is propagated in lineages in the absence of drug. This state is linked in cis to the treated centromere locus and correlates with inheritance of functionally defective centromeres and persistent chromosome segregation problems. Thus, assembly of fully functional centromeres is partly imprinted in the underacetylated or transcriptionally silent state of centromeric chromatin.

References

Jan 1, 1991·Methods in Enzymology·S MorenoP Nurse
Dec 1, 1990·Molecular and Cellular Biology·K G Ten HagenS N Cohen
Mar 23, 1990·Cell·J Tazi, A Bird
Jul 1, 1994·Nature Genetics·J M Craig, W A Bickmore
Jan 14, 1994·Cell·R C AllshireG Cranston
Aug 1, 1993·Molecular and Cellular Biology·N C SteinerL Clarke
Jul 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J H Hegemann, U N Fleig
Aug 1, 1995·Seminars in Cell Biology·B M Turner, L P O'Neill
Dec 1, 1996·Nucleic Acids Research·J P JaverzatR C Allshire
May 1, 1997·Nature·A P Wolffe

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Citations

Sep 25, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F Lyko, R Paro
Jul 27, 2000·Journal of Cellular Physiology·S I Grewal
Aug 17, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B M Turner
Sep 28, 2006·Current Genetics·Olga S FedyaninaEkaterina L Grishchuk
Oct 13, 2005·Chromosoma·Julie A Wallace, Terry L Orr-Weaver
Dec 7, 2005·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Anne W HigginsHuntington F Willard
Apr 22, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Laura Magnaghi-Jaulin, Christian Jaulin
Jun 29, 2012·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Luis P ValenteLars E T Jansen
May 26, 2004·Methods : a Companion to Methods in Enzymology·Alison PidouxRobin Allshire
Apr 23, 2003·Experimental Cell Research·Ilia I OuspenskiB R Brinkley
Oct 13, 2000·Cell·R Allshire, W Bickmore
Feb 14, 2004·Medical Hypotheses·Root Gorelick
May 10, 2000·Current Opinion in Cell Biology·A L Pidoux, R C Allshire
May 10, 2000·Current Opinion in Cell Biology·W L CheungC D Allis
Jun 18, 2002·Current Opinion in Cell Biology·Giacomo Cavalli
Jun 18, 2002·Current Opinion in Cell Biology·M Mitchell Smith
Jun 26, 1998·Current Opinion in Cell Biology·G Cavalli, R Paro
Feb 27, 1999·Current Opinion in Cell Biology·W S Saunders
Apr 8, 2000·Trends in Cell Biology·K H Choo
May 18, 2001·Trends in Cell Biology·T Jenuwein
Apr 21, 1999·Mutation Research·L BrodayM Costa
Nov 20, 2003·Nature Cell Biology·Julie M BailisSusan L Forsburg
Mar 20, 2010·Nature Reviews. Genetics·Raphaël Margueron, Danny Reinberg
Apr 24, 2007·Nature Structural & Molecular Biology·Estelle NicolasShiv I S Grewal
Apr 12, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T MunakataM Horikoshi
May 3, 2002·European Journal of Biochemistry·Pamela B Meluh, Alexander V Strunnikov
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Richard J Lawrence, Thomas A Volpe
May 7, 2010·The Journal of Biological Chemistry·Atsuko ShiraiJun-ichi Nakayama
Sep 13, 2001·Molecular Biology of the Cell·B KniolaK Ekwall
Dec 22, 2006·Molecular Biology of the Cell·Roberto PapaitIan Marc Bonapace
Jun 5, 1999·The EMBO Journal·J KoipallyK Georgopoulos
Nov 2, 2002·The EMBO Journal·Jonathan PerkRuth Shemer

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