Transient ipsilateral retinal ganglion cell projections to the brain: Extent, targeting, and disappearance

Developmental Neurobiology
Célia A Soares, Carol A Mason

Abstract

During development of the mammalian eye, the first retinal ganglion cells (RGCs) that extend to the brain are located in the dorsocentral (DC) retina. These RGCs extend to either ipsilateral or contralateral targets, but the ipsilateral projections do not survive into postnatal periods. The function and means of disappearance of the transient ipsilateral projection are not known. We have followed the course of this transient early ipsilateral cohort of RGCs, paying attention to how far they extend, whether they enter targets and if so, which ones, and the time course of their disappearance. The DC ipsilateral RGC axons were traced using DiI labeling at E13.5 and E15.5 to compare the proportion of ipsi- versus contralateral projections during the first period of growth. In utero electroporation of E12.5 retina with GFP constructs was used to label axons that could be visualized at succeeding time points into postnatal ages. Our results show that the earliest ipsilateral axons grow along the cellular border of the brain, and are segregated from the laterally positioned contralateral axons from the same retinal origin. In agreement with previous reports, although many early RGCs extend ipsilaterally, after E16 their number rapidly...Continue Reading

References

Mar 22, 1985·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·U C Dräger
Aug 8, 1985·The Journal of Comparative Neurology·B B Stanfield, D D O'Leary
Sep 21, 1984·Science·W M CowanB B Stanfield
Dec 20, 1984·The Journal of Comparative Neurology·P GodementM Imbert
Sep 16, 2003·Neuron·Scott E WilliamsMark Henkemeyer
Jul 19, 2005·Annual Review of Neuroscience·Liqun Luo, Dennis D M O'Leary
Jul 19, 2005·Annual Review of Neuroscience·Todd McLaughlin, Dennis D M O'Leary
Jul 19, 2005·Nature Neuroscience·Cory PfeiffenbergerDavid A Feldheim
Jan 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Takahiko Matsuda, Constance L Cepko
Mar 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sonya MarshakSusana Cohen-Cory
Sep 19, 2007·BMC Developmental Biology·Cristina Garcia-FrigolaEloisa Herrera
Jun 19, 2008·Annual Review of Neuroscience·Timothy J PetrosCarol A Mason
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Timothy J PetrosCarol Mason
Feb 27, 2010·Developmental Neurobiology·Susana Cohen-CorySonya Marshak
Jul 2, 2010·Cold Spring Harbor Perspectives in Biology·Jonathan Raper, Carol Mason
Oct 1, 2010·Cold Spring Harbor Perspectives in Biology·David A Feldheim, Dennis D M O'Leary
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Onkar S DhandeMichael C Crair
Mar 23, 2011·Neural Development·David S McNeillSamer Hattar
Apr 1, 2011·The Journal of Comparative Neurology·Y Kate HongJoshua R Sanes
Aug 27, 2011·Neuron·Jessica A OsterhoutAndrew D Huberman
Nov 23, 2011·The European Journal of Neuroscience·Takeshi Imai, Hitoshi Sakano
Dec 6, 2012·International Review of Neurobiology·Alan R HarveyJennifer Rodger
Dec 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David J SimonMarc Tessier-Lavigne
Jan 5, 2014·The Journal of Cell Biology·Douglas S Campbell, Hitoshi Okamoto
Mar 7, 2014·The European Journal of Neuroscience·Lorena Pont-LezicaAlain Bessis
Aug 19, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Javier Francisco-MorcilloGervasio Martín-Partido
Feb 25, 2015·Developmental Cell·Yoshifumi Yamaguchi, Masayuki Miura

❮ Previous
Next ❯

Citations

Dec 3, 2016·Developmental Neurobiology·Delphine S Prieur, Alexandra Rebsam
May 16, 2018·The Journal of Comparative Neurology·Florencia MarcucciCarol Mason
May 13, 2020·Annual Review of Vision Science·Carol Mason, Nefeli Slavi
Jun 9, 2020·Frontiers in Molecular Neuroscience·Russell J TaylorErik W Dent
Jul 7, 2019·International Journal of Molecular Sciences·Verónica Murcia-Belmonte, Lynda Erskine
Oct 20, 2018·Current Opinion in Neurobiology·Supraja G Varadarajan, Andrew D Huberman
Mar 31, 2021·Cellular and Molecular Life Sciences : CMLS·Jianyi Lyu, Xiuqian Mu
Oct 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jianmin SuMichael A Fox

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.