Transient leukemia followed by megakaryoblastic leukemia in a child with mosaic Down syndrome

Leukemia & Lymphoma
John J DoyleAlvin Zipursky

Abstract

A case is presented of a child with mosaic Down syndrome, who presented at birth with a transient leukemia and later progressed to megakaryoblastic leukemia. Evidence is presented that both leukemias were of megakaryoblastic lineage and evolved from a trisomic hematopoietic precursor. This case is unique in the poor course of the initial transient neonatal leukemia with improvement following chemotherapy. It also highlights the form of leukemia and associated myelodysplasia that occurs in children with Down syndrome. This form of leukemia and transient leukemia are interrelated and are unique to children with Down syndrome.

References

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Citations

Nov 24, 2004·Pediatric Blood & Cancer·Gita V Massey
Jun 29, 2007·Nature Clinical Practice. Oncology·Brandie HealdCharis Eng
Mar 21, 2002·Journal of Pediatric Hematology/oncology·Fawaz Al-KasimUNKNOWN Pediatric Oncology Group
May 22, 2003·Journal of Pediatric Hematology/oncology·Hart Isaacs
Jun 21, 2002·Veterinary Clinical Pathology·John K. DunnPhillip K. Nicholls
Sep 7, 2007·Veterinary Clinical Pathology·Steven E SuterCheryl A London
Nov 19, 2011·Veterinary Clinical Pathology·Helena M T FerreiraElspeth M Milne
Mar 22, 2003·British Journal of Haematology·Alvin Zipursky
Mar 1, 1994·Leukemia Research·A ZipurskyJ Doyle
Jan 1, 1996·Pediatric Hematology and Oncology·A ZipurskyJ Doyle
Sep 17, 2005·Leukemia Research·Adán ValladaresFabio Salamanca-Gómez

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