Transient liver dysfunction increases surgical site infections after coronary surgery

Asian Cardiovascular & Thoracic Annals
Rakan I NazerMazen Hassanain

Abstract

Background Surgical site infections can have a significant impact on cardiac surgical outcome. The liver plays an important role in infection prevention. This study aimed to retrospectively determine whether transient postoperative liver dysfunction after coronary bypass surgery increased surgical site infections. Methods A modified version of the Schindl scoring scale for liver dysfunction was adapted to objectively quantify transient liver dysfunction in the first 7 days after on-pump coronary artery bypass grafting. A retrospective analysis of clinical outcomes at 30 months postoperatively was performed on data of 575 patients who underwent coronary artery bypass between 2014 and 2016. The patients were categorized into a liver dysfunction group (Schindl score ≥ 4) and a non-liver dysfunction group (Schindl score < 4). Results The liver dysfunction group (47.3%) had significantly more patients who were obese, current smokers, and had diabetes, renal impairment, and peripheral vascular disease. Surgical site infections occurred predominantly in the liver dysfunction group (12.1% vs. 0.3%, p < 0.001). The independent predictors of surgical site infection were liver dysfunction, body mass index > 30 kg m-2, and coronary bypass ...Continue Reading

References

Mar 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P B L'EcuyerV J Fraser
May 15, 2004·The Journal of Hospital Infection·C L SwenneM Carlsson
Sep 18, 2004·Seminars in Cardiothoracic and Vascular Anesthesia·Eugene A Hessel
Jan 14, 2005·Gut·M J SchindlUNKNOWN Edinburgh Liver Surgery and Transplantation Experimental Research Group (eLISTER)
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vito Racanelli, Barbara Rehermann
Aug 20, 2014·Journal of Hepatology·Agustín AlbillosMelchor Álvarez-Mon
Apr 10, 2015·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Mazen HassanainPeter Metrakos
Jul 21, 2015·Journal of Cardiovascular and Thoracic Research·Feridoun Sabzi, Reza Faraji
Apr 5, 2016·Cellular & Molecular Immunology·Percy A Knolle, Dirk Wohlleber
Jan 17, 2017·Clinical & Translational Immunology·Dirk Wohlleber, Percy A Knolle

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Methods Mentioned

BETA
coronary bypass
coronary
coronary artery bypass

Software Mentioned

SAS
STAT
R

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