PMID: 6402161Feb 19, 1983Paper

Transient neonatal hyperthyrotrophinaemia: a serum abnormality due to transplacentally acquired antibody to thyroid stimulating hormone

British Medical Journal
J H LazarusR Hall

Abstract

In a screening programme for neonatal hypothyroidism an otherwise healthy female infant was found to have a high concentration of thyroid stimulating hormone in a filter paper blood spot and in serum. A high concentration was also found in the maternal serum. Mother and baby were both biochemically euthyroid with normal serum thyroxine concentrations. The apparently high concentration of thyroid stimulating hormone in the mother was due to the presence of an IgG antibody that bound to human but not bovine thyroid stimulating hormone. Maternal serum inhibited the action of human thyroid stimulating hormone in an in vitro bioassay for the hormone. It is suggested that the baby acquired the antibody transplacentally, especially as the concentration of thyroid stimulating hormone subsequently fell. It is concluded that maternal serum should be assayed for thyroid stimulating hormone when a neonate is found to have a high concentration of the hormone and a normal concentration of thyroxine to establish the incidence of this finding and to avoid inappropriate replacement treatment.

References

Dec 1, 1979·Archives of Disease in Childhood·K MiyaiT Oura
Apr 2, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·G S ChallandJ G Ratcliffe
Apr 15, 1975·FEBS Letters·R PlanellsJ Closset
Apr 1, 1981·Journal of Immunogenetics·B PepperN R Farid
Mar 1, 1981·The Journal of Endocrinology·J Bíró
Jul 1, 1981·The Journal of Clinical Endocrinology and Metabolism·G SchaisonM C Feinstein
Nov 10, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·R John, J S Woodhead
Mar 1, 1981·Annals of Clinical Biochemistry·S KaduryA B Kurtz
Jan 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·H B LEVY, H A SOBER

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Citations

Mar 1, 1991·European Journal of Pediatrics·L A TyfieldD C Savage
Aug 1, 1988·Baillière's Clinical Endocrinology and Metabolism·P Beck-Peccoz, G Medri
Jan 1, 1995·Baillière's Clinical Endocrinology and Metabolism·R Hall
Jun 1, 1985·Archives of Disease in Childhood·N D Barnes
Jan 1, 2009·BMJ Case Reports·Heidi MendozaRajeev Srivastava
Apr 2, 2009·Endocrine Journal·Hiroyuki SakaiMasato Odawara
Apr 29, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Eline VerhoyeMichel R Langlois
May 1, 1985·Clinics in Endocrinology and Metabolism·A A Gossage, D S Munro
Jan 1, 1991·Clinical Endocrinology·J H Lazarus, S Othman
Oct 28, 2016·Thyroid : Official Journal of the American Thyroid Association·Naoki HattoriAkira Shimatsu
Aug 1, 1995·Thyroid : Official Journal of the American Thyroid Association·H TamakiN Amino
Sep 1, 1986·Acta paediatrica Scandinavica·F A KarlssonI Felding
Oct 1, 1989·British Journal of Obstetrics and Gynaecology·T T Lao, N S Panesar
Jan 11, 2013·Clinical & Developmental Immunology·Akira Shimatsu, Naoki Hattori
May 16, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Alois GesslRodrig Marculescu
Apr 1, 1988·Scandinavian Journal of Clinical and Laboratory Investigation·K Rootwelt
Feb 1, 1988·Journal of Endocrinological Investigation·N JospeR L Humphrey
Jan 1, 1987·Annals of Clinical Biochemistry·R John
Jul 29, 2011·Annals of Clinical Biochemistry·Leanne ManningsCarol Evans
Sep 7, 2021·Frontiers in Endocrinology·Ana E Chiesa, Mariana L Tellechea
May 28, 2021·Endocrine Journal·Miho FukushitaKoichi Ito

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