PMID: 9523805Apr 2, 1998Paper

Transient neurologic symptoms after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine

Anesthesiology
K F HamplK Drasner

Abstract

Recent evidence suggests that transient neurologic symptoms (TNSs) frequently follow lidocaine spinal anesthesia but are infrequent with bupivacaine. However, identification of a short-acting local anesthetic to substitute for lidocaine for brief surgical procedures remains an important goal. Prilocaine is an amide local anesthetic with a duration of action similar to that of lidocaine. Accordingly, the present, prospective double-blind study compares prilocaine with lidocaine and bupivacaine with respect to duration of action and relative risk of TNSs. Ninety patients classified as American Society of Anesthesiologists physical status I or II who were scheduled for short gynecologic procedures under spinal anesthesia were randomly allocated to receive 2.5 ml 2% lidocaine in 7.5% glucose, 2% prilocaine in 7.5% glucose, or 0.5% bupivacaine in 7.5% glucose. All solutions were provided in blinded vials by the hospital pharmacy. Details of spinal puncture, extension and regression of spinal block, and the times to reach discharge criteria were noted. In the evening of postoperative day 1, patients were evaluated for TNSs by a physician unaware of the drug administered and the details of the anesthetic procedure. Nine of 30 patients...Continue Reading

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Citations

Feb 3, 2007·Der Anaesthesist·G RätschA Reber
Nov 25, 2000·Journal of Clinical Anesthesia·R R Gaiser
Oct 30, 1998·Journal of Clinical Anesthesia·F J Overdyk, S C Harvey
Apr 11, 2000·Acta Anaesthesiologica Scandinavica·G OstgaardH Flaatten
Jun 5, 2001·Anesthesiology·S S Liu, S B McDonald
Oct 4, 2006·Current Opinion in Anaesthesiology·K F HamplK Drasner
Oct 5, 2006·Current Opinion in Anaesthesiology·Stanley Muravchick
Oct 7, 2006·Current Opinion in Anaesthesiology·José L Aguilar, R Peláez
Dec 4, 2004·International Anesthesiology Clinics·Rajiv R Doshi, Jason Z Qu
Jun 2, 2000·Regional Anesthesia and Pain Medicine·P S HodgsonJ M Neal
May 23, 2002·Regional Anesthesia and Pain Medicine·Suzanne L HuffnagleValerie A Arkoosh
Nov 14, 2002·Regional Anesthesia and Pain Medicine·Julia E Pollock
Aug 16, 2011·Current Opinion in Anaesthesiology·Johannes G Förster, Per H Rosenberg
Feb 13, 2001·Anesthesia and Analgesia·M C Schneider, D J Birnbach
Nov 24, 2004·Drugs & Aging·Ban C H TsuiBrendan Finucane
Oct 8, 2003·Best Practice & Research. Clinical Anaesthesiology·Julia E Pollock
Jul 20, 2002·Regional Anesthesia and Pain Medicine·Yoshihiro HirabayashiNorimasa Seo
Jan 23, 1999·Anesthesiology·E J Youngs
Apr 9, 1999·Anesthesia and Analgesia·P S HodgsonS S Liu
Jan 8, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R MartinJ P Tétrault
Mar 31, 2001·The New England Journal of Medicine·J B LampeH Reichmann
Nov 2, 2002·Anesthesiology·Tomomune KishimotoKenneth Drasner
Aug 23, 2003·European Journal of Anaesthesiology·E ErhanB Ozyar
Dec 25, 2003·Anesthesia and Analgesia·Mary E Kouri, Dan J Kopacz
Sep 9, 2011·Paediatric Anaesthesia·Hannu Kokki
Dec 16, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Volker GebhardtMarc D Schmittner
Jun 25, 2005·Anesthesia and Analgesia·Shuichi KanekoTakefumi Sakabe
Oct 29, 2002·Anesthesia and Analgesia·Chester C BuckenmaierSusan M Steele
Apr 12, 2005·Drugs·Chester C Buckenmaier, Lisa L Bleckner
Jan 28, 2005·Anesthesia and Analgesia·Kenneth Drasner

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