PMID: 8603023Feb 1, 1996Paper

Transient normal platelet counts and decreased requirement for interferon during pregnancy in essential thrombocythaemia

British Journal of Haematology
O ShpilbergI Ben-Bassat

Abstract

We report on the remarkable decrease in the platelet counts during pregnancy in two women with essential thrombocythaemia following treatment with recombinant interferon-alpha (r-IFN-alpha). Prior to pregnancy, the first patient was treated for 10 months with r-IFN-alpha 3 x 10(6) units/d six times per week, and the platelet count ranged between 750 and 800 x 10(9)/l. Starting from the sixth week of gestation, the platelet count decreased to normal levels and remained so, resulting in a lower r-IFN-alpha requirement. Following successful delivery of a healthy newborn an abrupt rise of the platelet count to pre-gestation values was observed, necessitating increased r-IFN-alpha dosage before pregnancy. The second patient when she became pregnant had been treated with r-IFN-alpha 3 x 10(6) units/d six times per week for 10 weeks. Starting from the 24th week of gestation the platelet count decreased, and despite reduction in the dose of r-IFN-alpha reached normal values at the time of delivery. The exact mechanism for the platelet count normalization during pregnancy is unclear, and several possibilities are discussed.

Citations

May 17, 2003·Birth Defects Research. Part A, Clinical and Molecular Teratology·Janine E Polifka, J M Friedman
Nov 15, 2002·International Journal of Hematology·Tiziano Barbui
Jan 23, 1998·American Journal of Ophthalmology·K ShirakiY Kanaoka
May 5, 1999·Critical Reviews in Oncology/hematology·T Barbui, G Finazzi
May 24, 2003·Best Practice & Research. Clinical Haematology·Michelle A Elliott, Ayalew Tefferi
May 15, 2001·European Journal of Haematology·C A Wright, A Tefferi
Dec 19, 1998·British Journal of Haematology·M RuggeriT Barbui
Jun 13, 2002·British Journal of Haematology·Claire N Harrison
Jan 12, 2001·Journal of Clinical Gastroenterology·J F Trotter, A J Zygmunt
Jun 28, 2000·The Australian & New Zealand Journal of Obstetrics & Gynaecology·R CincottaS P Brennecke
Dec 29, 2000·Journal of Perinatal Medicine·M HiratsukaI Sato
Apr 22, 2005·British Journal of Haematology·Claire Harrison
Aug 2, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Brady P SeligJohn J Mulvihill
Dec 14, 2004·American Journal of Obstetrics and Gynecology·Pasquale MartinelliBruno Rotoli
Nov 4, 2004·European Journal of Haematology·Riitta NiittyvuopioTapani Ruutu
Jan 1, 1997·Hematology·T BarbuiT C Pearson
Aug 1, 1997·European Journal of Haematology·S J WilloughbyT C Pearson
Apr 2, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jacek KwiatkowskiRafał Małecki

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