Transient outward current, Ito1, is altered in cardiac memory

Circulation
H YuM R Rosen

Abstract

Cardiac memory refers to an altered T-wave morphology induced by ventricular pacing or arrhythmias that persist for variable intervals after resumption of sinus rhythm. We induced long-term cardiac memory (LTM) in conscious dogs by pacing the ventricles at 120 bpm for 3 weeks. ECGs were recorded daily for 1 hour, during which time pacing was discontinued. At terminal study, the heart was removed and the electrophysiology of left ventricular epicardial myocytes was investigated. Control (C) and LTM ECG did not differ, except for T-wave amplitude, which decreased from 0.12+/-0.18 to -0.34+/-0.21 mV (+/-SEM, P<0.05), and T-wave vector, which shifted from -37+/-12 degrees to -143+/-4 degrees (P<0.05). Epicardial action potentials revealed loss of the notch and lengthening of duration at 20 days (both P<0.05). Calcium-insensitive transient outward current (Ito) was investigated by whole-cell patch clamp. No difference in capacitance was seen in C and LTM myocytes. Ito activated on membrane depolarization to -25+/-1 mV in C and -7+/-1 mV (P<0.05) in LTM myocytes, indicating a positive voltage shift of activation. Ito density was reduced in LTM myocytes, and a decreased mRNA level for Kv4.3 was observed. Recovery of Ito from inactivat...Continue Reading

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Citations

Jul 4, 2009·Herz·Siegfried H Recke
Dec 4, 2004·Pflügers Archiv : European journal of physiology·Ravshan BaltaevGuiscard Seebohm
Mar 25, 2010·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Pablo A ChialeMarcelo V Elizari
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Mar 1, 2006·Progress in Biophysics and Molecular Biology·Fabien BretteLaurent Sallé
Feb 12, 2004·Journal of Molecular and Cellular Cardiology·Kornelis W Patberg, Michael R Rosen
Mar 29, 2001·Lancet·M R Rosen
Aug 23, 2002·Pharmacology & Therapeutics·Michael Rosen, Alexei Plotnikov
Oct 3, 2002·The Journal of Emergency Medicine·James C Kolb
Nov 16, 2001·Trends in Cardiovascular Medicine·S NattelG Schram
Jan 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Keith F DeckerYoram Rudy
Jun 24, 2010·BMC Cardiovascular Disorders·Li Yue-ChunLin Jia-Feng
May 10, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Junko SaitoTohru Izumi
Sep 9, 2008·Annals of Biomedical Engineering·Nico H L KuijpersPeter A J Hilbers
May 10, 2001·Journal of Molecular and Cellular Cardiology·G Y OuditP H Backx
Nov 15, 2005·The Journal of Physiology·Michael R Rosen, Ira S Cohen
Oct 16, 2001·The Journal of Physiology·S M AshamallaC A Ward
Feb 15, 2011·Trends in Pharmacological Sciences·Michael J CutlerDavid S Rosenbaum
Apr 13, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Marti F A Bierhuizen, Marc A Vos
Mar 30, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Nazira OzgenMichael R Rosen
Aug 18, 2009·The American Journal of Emergency Medicine·Carol Chen-Scarabelli, Tiziano M Scarabelli
Jun 30, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Alexei ShvilkinMark E Josephson
Mar 28, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Nazira Ozgen, Michael R Rosen
Mar 28, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Alexei Shvilkin
Mar 3, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Morten B ThomsenMichael R Rosen
May 20, 2008·Progress in Biophysics and Molecular Biology·Rachel StonesEd White
Dec 7, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Eugene A SosunovMichael R Rosen
Nov 13, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Liliane WeckeLennart Bergfeldt
Sep 18, 2007·The American Journal of Emergency Medicine·Ali A Sovari, Farhad Farokhi
Feb 27, 2007·International Journal of Cardiology·Kun-Tai LeeWen-Ter Lai
Jun 16, 2005·Pacing and Clinical Electrophysiology : PACE·Karolina NowinskiLennart Bergfeldt
Dec 20, 2005·Pacing and Clinical Electrophysiology : PACE·Gi-Byoung NamJong-Min Lee
Mar 11, 2009·Pacing and Clinical Electrophysiology : PACE·Mohammad KooshkabadiJonathan Langberg
Dec 13, 2005·Journal of Internal Medicine·M R Rosen, I S Cohen
Dec 23, 2009·Pacing and Clinical Electrophysiology : PACE·Darwin JeyarajDavid S Rosenbaum
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Dirk VollmannMaurits Allessie
Dec 20, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kornelis W PatbergMichael R Rosen
Dec 3, 2005·International Journal of Cardiology·Maria Aunes-JanssonNils Edvardsson
Nov 3, 2004·Journal of the American College of Cardiology·Maher NahlawiJeffrey J Goldberger
Nov 11, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Michael R Rosen
Jun 22, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·E CerbaiA Mugelli

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