PMID: 16501819Feb 28, 2006Paper

Transient outward potassium current and Ca2+ homeostasis in the heart: beyond the action potential

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
R A Bassani

Abstract

The present review deals with Ca2+-independent, K+-carried transient outward current (Ito), an important determinant of the early repolarization phase of the myocardial action potential. The density of total Ito and of its fast and slow components (I(to,f) and I(to,s), respectively), as well as the expression of their molecular correlates (pore-forming protein isoforms Kv4.3/4.2 and Kv1.4, respectively), vary during postnatal development and aging across species and regions of the heart. Changes in Ito may also occur in disease conditions, which may affect the profile of cardiac repolarization and vulnerability to arrhythmias, and also influence excitation-contraction coupling. Decreased Ito density, observed in immature and aging myocardium, as well as during several types of cardiomyopathy and heart failure, may be associated with action potential prolongation, which favors Ca2+ influx during membrane depolarization and limits voltage-dependent Ca2+ efflux via the Na+/Ca2+ exchanger. Both effects contribute to increasing sarcoplasmic reticulum (SR) Ca2+ content (the main source of contraction-activating Ca2+ in mammalian myocardium), which, in addition to the increased Ca2+ influx, should enhance the amount of Ca2+ released b...Continue Reading

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Citations

Dec 15, 2010·European Heart Journal·Thitima KeskanokwongYanggan Wang
Jul 31, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Katja E OdeningDaniela Föll
Aug 2, 2011·Journal of Molecular and Cellular Cardiology·E P ScholzE Zitron
Jul 28, 2009·Journal of Molecular and Cellular Cardiology·Norbert NagyAndrás Tóth
May 24, 2016·Progress in Biophysics and Molecular Biology·C N LangK E Odening
Oct 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Claudio CeconiRoberto Ferrari
May 30, 2021·Heart·Lucas Miranda KangussuDaniella Bonaventura

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