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Transient overexposure of neuregulin 3 during early postnatal development impacts selective behaviors in adulthood

PloS One

Aug 6, 2014

Clare Paterson, Amanda J Law

Abstract

Neuregulin 3 (NRG3), a specific ligand for ErbB4 and a neuronal-enriched neurotrophin is implicated in the genetic predisposition to a broad spectrum of neurodevelopmental, neurocognitive and neuropsychiatric disorders, including Alzheimer's disease, autism and schizophrenia. Genetic st...read more

Mentioned in this Paper

Examination of Reflexes
ErbB-2 Receptor
ERBB3 gene
Blood - Brain Barrier Anatomy
Brain Diseases
Amphetamine
Exertion
Neurologic Manifestations
Prefrontal Cortex
ERBB4 gene
1
55
Paper Details
References
  • References53
  • Citations13
12345...
  • References53
  • Citations13
12

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Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain

Proceedings of the National Academy of Sciences of the United States of AmericaAugust 18, 2010
Wee-Tin KaoAmanda J Law
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Transient overexposure of neuregulin 3 during early postnatal development impacts selective behaviors in adulthood

PloS One

Aug 6, 2014

Clare Paterson, Amanda J Law

PMID: 25093331

DOI: 10.1371/journal.pone.0104172

Abstract

Neuregulin 3 (NRG3), a specific ligand for ErbB4 and a neuronal-enriched neurotrophin is implicated in the genetic predisposition to a broad spectrum of neurodevelopmental, neurocognitive and neuropsychiatric disorders, including Alzheimer's disease, autism and schizophrenia. Genetic st...read more

Mentioned in this Paper

Examination of Reflexes
ErbB-2 Receptor
ERBB3 gene
Blood - Brain Barrier Anatomy
Brain Diseases
Amphetamine
Exertion
Neurologic Manifestations
Prefrontal Cortex
ERBB4 gene
1
55

Similar Papers Found In These Feeds

Cognitive Flexibility and Anxiety

Anxiety and stress can impact cognitive flexibility of an individual, involving prefrontal cortex. Here is the latest research.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain

Proceedings of the National Academy of Sciences of the United States of AmericaAugust 18, 2010
Wee-Tin KaoAmanda J Law
Paper Details
References
  • References53
  • Citations13
12345...
  • References53
  • Citations13
12
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