Transient pancytopenia preceding adult acute lymphoblastic leukemia with chromosomal abnormalities including the Philadelphia chromosome: A case report and review of the literature

Oncology Letters
Yun LiangXiaohong Zhang

Abstract

A preleukaemic phase, typified by transient pancytopenia, is a rare occurrence that usually affects children and adolescents. The present study reports the case of a 50-year-old woman with transient pancytopenia, which manifested as a fever, cough and severe anemia. Three weeks following treatment of pancytopenia with antibiotics, red blood cell and platelet transfusion, granulocyte colony-stimulating factor and human γ globulin, the condition of the patient was improved. However, 3 weeks following discharge from hospital, the patient was diagnosed with acute lymphoblastic leukemia (ALL) with complex chromosomal abnormalities, including Philadelphia chromosome and P190 breakpoint cluster region-ABL. Complete remission was achieved following one course of combination chemotherapy. In conclusion, adult ALL with pancytopenia as a preceding symptom is rare, difficult to diagnose early and easily misdiagnosed. In addition, the pathogenesis of ALL and the precipitating factors underlying this disease require further investigation.

References

Jan 1, 1993·Cancer·Y H MatloubN K Ramsay
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A MajlisH M Kantarjian
Apr 16, 1998·The Korean Journal of Internal Medicine·S K SohnK B Lee
Sep 21, 2001·British Journal of Haematology·E D HeegaardK Schmiegelow
Sep 4, 2004·Acta Haematologica·Hui ZhaoZhong Chao Han
Jan 9, 2008·Genes, Chromosomes & Cancer·Sharon W HorsleyLyndal Kearney
Oct 11, 2012·Revista brasileira de hematologia e hemoterapia·Laura Villarreal-MartínezDavid Gómez-Almaguer

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Citations

Dec 30, 2017·Oncology Letters·Timm HöresKerstin Schaefer-Eckart

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