Transient phenomena in gene expression after induction of transcription.

PloS One
Carlus DenekeAngelo Valleriani

Abstract

When transcription of a gene is induced by a stimulus, the number of its mRNA molecules changes with time. Here we discuss how this time evolution depends on the shape of the mRNA lifetime distribution. Analysis of the statistical properties of this change reveals transient effects on polysomes, ribosomal profiles, and rate of protein synthesis. Our studies reveal that transient phenomena in gene expression strongly depend on the specific form of the mRNA lifetime distribution.

References

Jul 1, 1990·Molecular Microbiology·N Jacques, M Dreyfus
Jun 1, 1995·Current Opinion in Immunology·J JainA Rao
Feb 17, 2000·The EMBO Journal·P J LewisJ Errington
May 16, 2000·Journal of Bacteriology·S T LiangH Bremer
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·M Thattai, A van Oudenaarden
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jonathan A BernsteinStanley N Cohen
Mar 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yoav AravaDaniel Herschlag
Jul 16, 2008·Journal of Molecular Biology·Namiko MitaraiSteen Pedersen
Jan 27, 2009·Cell·Florian BrandtWolfgang Baumeister
Apr 3, 2010·Nucleic Acids Research·Gong ZhangZoya Ignatova
May 21, 2010·Genome Biology·Claudia SteglichSallie W Chisholm
Jun 4, 2010·Nature Reviews. Molecular Cell Biology·Joel G Belasco
Feb 26, 2011·Science·Keren Nevo-DinurOrna Amster-Choder
May 24, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Angelo VallerianiReinhard Lipowsky

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Citations

Feb 10, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Alexander BartholomäusZoya Ignatova
May 18, 2016·PloS One·Celine SinAngelo Valleriani
Apr 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Denis Nchang CheSeon Il Jang
Jul 26, 2013·Physical Biology·Carlus DenekeAngelo Valleriani

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