PMID: 11605994Oct 19, 2001Paper

Transient pleural effusion in norepinephrine-stimulated rats

Basic Research in Cardiology
Beate RasslerH G Zimmer

Abstract

Transient pleural effusions occurred in rats receiving continuous intravenous infusion of norepinephrine (NE, 0.1 mg/kg/h). We hypothesized that these pleural effusions result from a NE-induced increase in right ventricular systolic pressure (RVSP) and total peripheral resistance (TPR). NE was administered over time intervals between 20 min and 72 h. It induced an immediate doubling in RVSP whereas LVSP remained at the control level. TPR increased with a delay of 6 h. At this time, pleural effusions occurred in NE-treated animals, reached their maximum after 8h and disappeared after 24 h of NE stimulation. Combining NE with the alpha-blocker prazosin normalized TPR and prevented pleural effusions. Therefore, we interpret the pleural effusion as a consequence of pulmonary venous congestion, mainly caused by an increased TPR. LV hypertrophy which developed after 24 h of NE stimulation is considered to compensate for the hemodynamic disturbance due to the NE-induced elevation in TPR. This is reflected in the disappearance of pleural effusion.

Citations

Apr 23, 2003·Respiratory Physiology & Neurobiology·Beate RasslerHeinz Gerd Zimmer
Jun 29, 2007·Respiratory Physiology & Neurobiology·Beate RasslerHeinz-Gerd Zimmer
Dec 17, 2014·Journal of Neurotrauma·Jiří ŠedýJosef Zicha
Nov 23, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Beate RasslerHeinz-Gerd Zimmer
Dec 15, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A SalamehS Dhein

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