Transient receptor potential A1 receptor-mediated neural cross-talk and afferent sensitization induced by oxidative stress: implication for the pathogenesis of interstitial cystitis/bladder pain syndrome

International Journal of Urology : Official Journal of the Japanese Urological Association
Akira FurutaNaoki Yoshimura

Abstract

Although the pathogenesis of interstitial cystitis/bladder pain syndrome remains unknown, there is a significant correlation of interstitial cystitis/bladder pain syndrome with other chronic pain disorders, such as irritable bowel syndrome, endometriosis and fibromyalgia syndrome. In this review, we highlight evidence supporting neural cross-talk in the dorsal root ganglia, spinal cord and brain levels, which might play a role in the development of chronic pain disorders through central sensitization. In addition, we focus on transient receptor potential V1 and transient receptor potential A1 as the receptor targets for chronic pain conditions, because transient receptor potential V1 and transient receptor potential A1 act as a nocisensor to mediate not only an afferent signal to the dorsal horn of the spinal cord, but also an efferent signal in the periphery through secretion of inflammatory agents, such as substance P and calcitonin gene-related peptide in nociceptive sensory neurons. Furthermore, peripheral inflammation produces multiple inflammatory mediators that act on their cognate receptors to activate intracellular signal transduction pathways and thereby modify the expression and function of transient receptor potenti...Continue Reading

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Citations

Sep 25, 2012·Pflügers Archiv : European journal of physiology·Bernd NiliusGrzegorz Owsianik
May 16, 2014·International Urogynecology Journal·Akira FurutaNaoki Yoshimura
May 3, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Yaw-Bin HuangPao-Chu Wu
Jan 20, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Tomonori Minagawa, Osamu Ishizuka
Jun 11, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Michael J WorleyShu-Wing Ng
Oct 10, 2014·Reproductive Sciences·B A LesseyK Chwalisz
Oct 8, 2020·Reviews on Recent Clinical Trials·Basant K Puri, Gary S Lee

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