Transient receptor potential (TRP) channels as molecular targets in lung toxicology and associated diseases

Cell Calcium
Alexander DietrichThomas Gudermann

Abstract

The lungs as the gateways of our body to the external environment are essential for gas exchange. They are also exposed to toxicants from two sides, the airways and the vasculature. Apart from naturally produced toxic agents, millions of human made chemicals were produced since the beginning of the industrial revolution whose toxicity still needs to be determined. While the knowledge about toxic substances is increasing only slowly, a paradigm shift regarding the proposed mechanisms of toxicity at the plasma membrane emerged. According to their broad-range chemical reactivity, the mechanism of lung injury evoked by these agents has long been described as rather unspecific. Consequently, therapeutic options are still restricted to symptomatic treatment. The identification of molecular down-stream effectors in cells was a major step forward in the mechanistic understanding of the action of toxic chemicals and will pave the way for more causal and specific toxicity testing as well as therapeutic options. In this context, the involvement of Transient Receptor Potential (TRP) channels as chemosensors involved in the detection and effectors of toxicant action is an attractive concept intensively discussed in the scientific community....Continue Reading

Citations

Apr 20, 2018·Acta Pharmacologica Sinica·Jillian Corinne Belrose, Michael Frederick Jackson
May 14, 2018·Pflügers Archiv : European journal of physiology·Martina KannlerAlexander Dietrich
Jul 18, 2018·The Journal of Physiology·Szandor SimmonsWolfgang M Kuebler
Jun 7, 2019·American Journal of Respiratory and Critical Care Medicine·Samuel ChungMatthias Salathe
Nov 2, 2019·Physiological Reviews·Karel TalaveraBernd Nilius
Apr 15, 2020·Antioxidants & Redox Signaling·Mobarak Abu MraheilRudolf Lucas
Sep 7, 2020·Annals of the New York Academy of Sciences·Satyanarayana Achanta, Sven-Eric Jordt
Dec 12, 2018·MAbs·Catherine J HutchingsTheodore G Clark
Jul 10, 2019·Oxidative Medicine and Cellular Longevity·Mengmeng XuFeng Li
Feb 1, 2020·Pharmacology & Therapeutics·Hongbo WangMichael X Zhu
Jan 27, 2020·Toxicology Letters·M Pesonen, K Vähäkangas
May 1, 2021·Cells·Suhasini RajanAlexander Dietrich
May 14, 2021·International Journal of Immunopathology and Pharmacology·Guangyi BaWeitian Zhang
Aug 7, 2021·Biomedicines·Oxana Yu KytikovaJuliy M Perelman

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