Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 contribute to the progression of colonic inflammation in dextran sulfate sodium-induced colitis in mice: Links to calcitonin gene-related peptide and substance P

Journal of Pharmacological Sciences
Daichi UtsumiShinichi Kato

Abstract

Transient receptor potential (TRP) vanilloid 1 (TRPV1) and TRP ankyrin 1 (TRPA1), which are non-selective cation channels, play important roles in the sensation of pain. This study investigated the roles of TRPV1 and TRPA1 in dextran sulfate sodium (DSS)-induced murine colitis. DSS (2%) administered for 7 days caused severe colitis that was significantly less severe in TRPV1-deficient (TRPV1KO) and TRPA1-deficient (TRPA1KO) mice than that in wild-type (WT) mice. Similar colitis attenuations were observed in TRPV1KO and TRPA1KO mice but not in WT mice that had been transplanted with bone marrow cells from WT, TRPA1KO, or TRPV1KO mice. DSS treatment upregulated calcitonin gene-relative peptide (CGRP)- and substance P (SP)-positive nerve fibers in the colonic mucosa of WT mice. TRPV1KO and TRPA1KO mice showed significant reductions in the DSS-induced upregulation of SP, but the DSS-induced upregulation of CGRP was not reduced. Sensory deafferentation evoked by pretreatment with high doses of capsaicin markedly exacerbated DSS-induced colitis with reductions in DSS-induced upregulation of SP- and CGRP-positive nerve fibers. These findings suggest that neuronal TRPV1 and TRPA1 contribute to the progression of colonic inflammation. W...Continue Reading

Citations

Nov 2, 2019·Physiological Reviews·Karel TalaveraBernd Nilius
Mar 11, 2020·Frontiers in Immunology·Yiding ChenHu Zhang
Oct 28, 2019·International Journal of Molecular Sciences·Alessandro Alaimo, Josep Rubert
Mar 13, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Charles E NortonErika M Boerman
Mar 15, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Koji KobayashiTakahisa Murata
Feb 12, 2019·Cellular and Molecular Gastroenterology and Hepatology·Wilmarie Morales-Soto, Brian D Gulbransen
May 15, 2021·British Journal of Pharmacology·Ivan TochitskyClifford J Woolf
May 29, 2021·Endocrinology·Melissa E LenertMichael D Burton
Oct 9, 2021·The Journal of Pharmacology and Experimental Therapeutics·Ehsan Noor-MohammadiBeverley Greenwood-Van Meerveld

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